BRD-A52530684_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-A52530684_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALOX5 arachidonate 5-lipoxygenase
AQP1 aquaporin 1 (Colton blood group)
CD47 CD47 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CP ceruloplasmin (ferroxidase)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EHD3 EH-domain containing 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FBXO11 F-box protein 11
HBB hemoglobin, beta
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
MARCO macrophage receptor with collagenous structure
NEBL nebulette
NLRP2 NLR family, pyrin domain containing 2
REEP5 receptor accessory protein 5
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM47 transmembrane protein 47
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FAM60A family with sequence similarity 60, member A
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
GABPB1 GA binding protein transcription factor, beta subunit 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
JMJD6 jumonji domain containing 6
KIZ kizuna centrosomal protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MED1 mediator complex subunit 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
PLAC8 placenta-specific 8
RHOB ras homolog family member B
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TSKU tsukushi, small leucine rich proteoglycan
VGLL4 vestigial-like family member 4
WEE1 WEE1 G2 checkpoint kinase