BRD-A49680073_Cucurbitacin I_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-A49680073_Cucurbitacin I_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BAG3 BCL2-associated athanogene 3
C14ORF132 chromosome 14 open reading frame 132
C1QA complement component 1, q subcomponent, A chain
C5AR1 complement component 5a receptor 1
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CBS cystathionine-beta-synthase
CD14 CD14 molecule
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLEC2B C-type lectin domain family 2, member B
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5A eukaryotic translation initiation factor 5A
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FMOD fibromodulin
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GAGE3 G antigen 3
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAS GNAS complex locus
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFRD1 interferon-related developmental regulator 1
KLF4 Kruppel-like factor 4 (gut)
LPAR2 lysophosphatidic acid receptor 2
LYPD1 LY6/PLAUR domain containing 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MXI1 MAX interactor 1, dimerization protein
NCAM1 neural cell adhesion molecule 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLPI secretory leukocyte peptidase inhibitor
SOX11 SRY (sex determining region Y)-box 11
SQSTM1 sequestosome 1
SST somatostatin
TDO2 tryptophan 2,3-dioxygenase
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
VSIG4 V-set and immunoglobulin domain containing 4
WARS tryptophanyl-tRNA synthetase
WFDC1 WAP four-disulfide core domain 1
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AMD1 adenosylmethionine decarboxylase 1
CCL19 chemokine (C-C motif) ligand 19
CCND1 cyclin D1
CCNE2 cyclin E2
CD59 CD59 molecule, complement regulatory protein
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DLC1 DLC1 Rho GTPase activating protein
DST dystonin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FTO fat mass and obesity associated
GADD45B growth arrest and DNA-damage-inducible, beta
GPX1 glutathione peroxidase 1
GRWD1 glutamate-rich WD repeat containing 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HOXA10 homeobox A10
HOXC6 homeobox C6
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INSIG1 insulin induced gene 1
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MOK MOK protein kinase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NT5DC2 5'-nucleotidase domain containing 2
PLAC8 placenta-specific 8
RAI14 retinoic acid induced 14
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCAN1 regulator of calcineurin 1
RPIA ribose 5-phosphate isomerase A
RPS4Y1 ribosomal protein S4, Y-linked 1
SFN stratifin
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPRR1A small proline-rich protein 1A
SRPX sushi-repeat containing protein, X-linked
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TSPAN8 tetraspanin 8
ZBTB18 zinc finger and BTB domain containing 18