BRD-A47714657_2-methoxy-5-((6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenol KCR-2_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

40 genes differentially expressed following the BRD-A47714657_2-methoxy-5-((6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)phenol KCR-2_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
C10ORF10 chromosome 10 open reading frame 10
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD3D CD3d molecule, delta (CD3-TCR complex)
CD93 CD93 molecule
CORO1A coronin, actin binding protein, 1A
CSRP2 cysteine and glycine-rich protein 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM107A family with sequence similarity 107, member A
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFI16 interferon, gamma-inducible protein 16
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP7 insulin-like growth factor binding protein 7
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
MAN1A1 mannosidase, alpha, class 1A, member 1
NFE2L2 nuclear factor, erythroid 2-like 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PELI1 pellino E3 ubiquitin protein ligase 1
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCGB1D2 secretoglobin, family 1D, member 2
SNX7 sorting nexin 7
SPRED2 sprouty-related, EVH1 domain containing 2
VWF von Willebrand factor

decreased expression

Symbol Name
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CA12 carbonic anhydrase XII
CCNI cyclin I
CHPT1 choline phosphotransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
GNAS GNAS complex locus
KYNU kynureninase
NPY neuropeptide Y
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPIG peptidylprolyl isomerase G (cyclophilin G)
TMPRSS2 transmembrane protease, serine 2