BRD-A46747628_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-A46747628_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
AHSG alpha-2-HS-glycoprotein
AKAP8L A kinase (PRKA) anchor protein 8-like
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
APOA2 apolipoprotein A-II
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPN asporin
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL6 B-cell CLL/lymphoma 6
BIRC2 baculoviral IAP repeat containing 2
CD36 CD36 molecule (thrombospondin receptor)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFLAR CASP8 and FADD-like apoptosis regulator
CHIC2 cysteine-rich hydrophobic domain 2
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL5A2 collagen, type V, alpha 2
COL9A3 collagen, type IX, alpha 3
CPVL carboxypeptidase, vitellogenic-like
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP2 cysteine and glycine-rich protein 2
CST1 cystatin SN
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELF1 E74-like factor 1 (ets domain transcription factor)
F2RL1 coagulation factor II (thrombin) receptor-like 1
F5 coagulation factor V (proaccelerin, labile factor)
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FNDC3B fibronectin type III domain containing 3B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GSTM3 glutathione S-transferase mu 3 (brain)
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IGFBP1 insulin-like growth factor binding protein 1
IL6ST interleukin 6 signal transducer
KLF9 Kruppel-like factor 9
LEF1 lymphoid enhancer-binding factor 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MED13 mediator complex subunit 13
MYO10 myosin X
PAX6 paired box 6
PDLIM5 PDZ and LIM domain 5
PHACTR2 phosphatase and actin regulator 2
PKN2 protein kinase N2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PSPH phosphoserine phosphatase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RNF13 ring finger protein 13
RNF43 ring finger protein 43
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3BP4 SH3-domain binding protein 4
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TF transferrin
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
TMEM123 transmembrane protein 123
TNS3 tensin 3
TXNIP thioredoxin interacting protein
VNN1 vanin 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
AHNAK2 AHNAK nucleoprotein 2
ANK2 ankyrin 2, neuronal
ANXA6 annexin A6
ARMCX1 armadillo repeat containing, X-linked 1
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPP19 cAMP-regulated phosphoprotein, 19kDa
C14ORF132 chromosome 14 open reading frame 132
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CAV1 caveolin 1, caveolae protein, 22kDa
CDC25B cell division cycle 25B
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DES desmin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DND1 DND microRNA-mediated repression inhibitor 1
DPYSL2 dihydropyrimidinase-like 2
EIF5 eukaryotic translation initiation factor 5
FAR2 fatty acyl CoA reductase 2
FLG filaggrin
FSCN1 fascin actin-bundling protein 1
GATA3 GATA binding protein 3
GPNMB glycoprotein (transmembrane) nmb
HN1 hematological and neurological expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IGKC immunoglobulin kappa constant
JCHAIN joining chain of multimeric IgA and IgM
KIF1BP KIF1 binding protein
LPCAT1 lysophosphatidylcholine acyltransferase 1
MLPH melanophilin
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NQO1 NAD(P)H dehydrogenase, quinone 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDZK1IP1 PDZK1 interacting protein 1
PRKCB protein kinase C, beta
PRUNE2 prune homolog 2 (Drosophila)
PSIP1 PC4 and SFRS1 interacting protein 1
PTN pleiotrophin
RNF167 ring finger protein 167
RPL10 ribosomal protein L10
RTN2 reticulon 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFN stratifin
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
STEAP3 STEAP family member 3, metalloreductase
STX1A syntaxin 1A (brain)
SYBU syntabulin (syntaxin-interacting)
TUBA4A tubulin, alpha 4a
TXNDC9 thioredoxin domain containing 9
ZW10 zw10 kinetochore protein