BRD-A45657137_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-A45657137_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPT2 angiopoietin 2
ANXA1 annexin A1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BAD BCL2-associated agonist of cell death
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD93 CD93 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CRABP1 cellular retinoic acid binding protein 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYD dihydropyrimidine dehydrogenase
EDN1 endothelin 1
EPAS1 endothelial PAS domain protein 1
ETV5 ets variant 5
FZD10 frizzled class receptor 10
FZD6 frizzled class receptor 6
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXB2 homeobox B2
IDO1 indoleamine 2,3-dioxygenase 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGKC immunoglobulin kappa constant
INA internexin neuronal intermediate filament protein, alpha
INHBB inhibin, beta B
JCHAIN joining chain of multimeric IgA and IgM
KIAA0196 KIAA0196
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PCLO piccolo presynaptic cytomatrix protein
PLEKHA5 pleckstrin homology domain containing, family A member 5
PRKCI protein kinase C, iota
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCPEP1 serine carboxypeptidase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SHB Src homology 2 domain containing adaptor protein B
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TES testin LIM domain protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMSB15A thymosin beta 15a
TP63 tumor protein p63
TWIST1 twist family bHLH transcription factor 1
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
ZNF217 zinc finger protein 217

decreased expression

Symbol Name
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ARF4 ADP-ribosylation factor 4
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATXN1 ataxin 1
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM46A family with sequence similarity 46, member A
FAM57A family with sequence similarity 57, member A
FKBP11 FK506 binding protein 11, 19 kDa
GSTA4 glutathione S-transferase alpha 4
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIF20A kinesin family member 20A
LRP4 low density lipoprotein receptor-related protein 4
LTF lactotransferrin
MAMLD1 mastermind-like domain containing 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK13 mitogen-activated protein kinase 13
MCOLN1 mucolipin 1
METTL7A methyltransferase like 7A
MSH6 mutS homolog 6
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
PROM1 prominin 1
PURA purine-rich element binding protein A
RNASET2 ribonuclease T2
SACS sacsin molecular chaperone
SELL selectin L
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIAH2 siah E3 ubiquitin protein ligase 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPATS2L spermatogenesis associated, serine-rich 2-like
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMBIM6 transmembrane BAX inhibitor motif containing 6
TSPAN8 tetraspanin 8