BRD-A45498368_WYE-125132_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-A45498368_WYE-125132_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL2 angiopoietin-like 2
ANXA4 annexin A4
BHLHE41 basic helix-loop-helix family, member e41
CCNG2 cyclin G2
CFD complement factor D (adipsin)
CHMP4A charged multivesicular body protein 4A
CP ceruloplasmin (ferroxidase)
DDR1 discoidin domain receptor tyrosine kinase 1
DOK5 docking protein 5
DUSP22 dual specificity phosphatase 22
DUSP3 dual specificity phosphatase 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EIF4B eukaryotic translation initiation factor 4B
EPAS1 endothelial PAS domain protein 1
ETFB electron-transfer-flavoprotein, beta polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FAM134A family with sequence similarity 134, member A
FXR1 fragile X mental retardation, autosomal homolog 1
GAA glucosidase, alpha; acid
GLRX glutaredoxin (thioltransferase)
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GRN granulin
HMOX1 heme oxygenase 1
HS1BP3 HCLS1 binding protein 3
ICAM1 intercellular adhesion molecule 1
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAG1 jagged 1
KLHL24 kelch-like family member 24
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LGALS3 lectin, galactoside-binding, soluble, 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MLPH melanophilin
MMP1 matrix metallopeptidase 1
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPC1 Niemann-Pick disease, type C1
NPIPB3 nuclear pore complex interacting protein family, member B3
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PROS1 protein S (alpha)
RB1CC1 RB1-inducible coiled-coil 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RRAGD Ras-related GTP binding D
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAB1 stabilin 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCEAL4 transcription elongation factor A (SII)-like 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TPP1 tripeptidyl peptidase I
USP34 ubiquitin specific peptidase 34
VAT1 vesicle amine transport 1
WDR19 WD repeat domain 19

decreased expression

Symbol Name
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CLIC3 chloride intracellular channel 3
COL5A1 collagen, type V, alpha 1
COPS3 COP9 signalosome subunit 3
CTPS1 CTP synthase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EED embryonic ectoderm development
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FEN1 flap structure-specific endonuclease 1
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRIA2 glutamate receptor, ionotropic, AMPA 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HSPA4L heat shock 70kDa protein 4-like
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
IGHM immunoglobulin heavy constant mu
INA internexin neuronal intermediate filament protein, alpha
MAP7 microtubule-associated protein 7
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MMP9 matrix metallopeptidase 9
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
PCNA proliferating cell nuclear antigen
PLAC8 placenta-specific 8
PLBD1 phospholipase B domain containing 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCGB2A2 secretoglobin, family 2A, member 2
SPP1 secreted phosphoprotein 1
SRM spermidine synthase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TK1 thymidine kinase 1, soluble
TMEM176B transmembrane protein 176B
TMPO thymopoietin
TRDV3 T cell receptor delta variable 3
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
TUBG1 tubulin, gamma 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UNG uracil-DNA glycosylase
ZWINT ZW10 interacting kinetochore protein