BRD-A45498368_WYE-125132_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-A45498368_WYE-125132_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADGRG6 adhesion G protein-coupled receptor G6
BACE2 beta-site APP-cleaving enzyme 2
CCNG2 cyclin G2
CD200 CD200 molecule
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CLIC5 chloride intracellular channel 5
CRIP1 cysteine-rich protein 1 (intestinal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOCK9 dedicator of cytokinesis 9
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
GAB2 GRB2-associated binding protein 2
GAS6 growth arrest-specific 6
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPX3 glutathione peroxidase 3
GSN gelsolin
HLA-E major histocompatibility complex, class I, E
HOXD1 homeobox D1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
JUP junction plakoglobin
LGALS3 lectin, galactoside-binding, soluble, 3
LXN latexin
MACF1 microtubule-actin crosslinking factor 1
MBNL2 muscleblind-like splicing regulator 2
MSLN mesothelin
MX1 MX dynamin-like GTPase 1
MYRF myelin regulatory factor
N4BP2L1 NEDD4 binding protein 2-like 1
NPDC1 neural proliferation, differentiation and control, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PDZD2 PDZ domain containing 2
PLK2 polo-like kinase 2
PMP22 peripheral myelin protein 22
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTPRE protein tyrosine phosphatase, receptor type, E
RAB4A RAB4A, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SH3YL1 SH3 and SYLF domain containing 1
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SST somatostatin
TIMP2 TIMP metallopeptidase inhibitor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAPPC6A trafficking protein particle complex 6A
WT1 Wilms tumor 1
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CALB1 calbindin 1, 28kDa
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CDC25A cell division cycle 25A
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EXOSC4 exosome component 4
FABP7 fatty acid binding protein 7, brain
GCLM glutamate-cysteine ligase, modifier subunit
GRB14 growth factor receptor-bound protein 14
GSTA1 glutathione S-transferase alpha 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA10 homeobox A10
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
LBR lamin B receptor
LTF lactotransferrin
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP9 matrix metallopeptidase 9
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
MYLK myosin light chain kinase
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
OLFM4 olfactomedin 4
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
RAD23B RAD23 homolog B (S. cerevisiae)
RRM2 ribonucleotide reductase M2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SORD sorbitol dehydrogenase
SQLE squalene epoxidase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TRAPPC3 trafficking protein particle complex 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)