BRD-A45498368_WYE-125132_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

229 genes differentially expressed following the BRD-A45498368_WYE-125132_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANGPTL2 angiopoietin-like 2
ANKRD36B ankyrin repeat domain 36B
C11ORF95 chromosome 11 open reading frame 95
CAPRIN2 caprin family member 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND1 cyclin D1
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CEP68 centrosomal protein 68kDa
CFD complement factor D (adipsin)
CHRDL1 chordin-like 1
CIRBP cold inducible RNA binding protein
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSF cathepsin F
CTSK cathepsin K
DCN decorin
DEFB1 defensin, beta 1
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
EGR1 early growth response 1
EGR3 early growth response 3
EIF3D eukaryotic translation initiation factor 3, subunit D
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD2 FXYD domain containing ion transport regulator 2
GAB2 GRB2-associated binding protein 2
GAS6 growth arrest-specific 6
GPR137B G protein-coupled receptor 137B
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSE1 Gse1 coiled-coil protein
HDAC6 histone deacetylase 6
HIST1H2AC histone cluster 1, H2ac
HMGA2 high mobility group AT-hook 2
HOXD1 homeobox D1
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JADE2 jade family PHD finger 2
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LAMC2 laminin, gamma 2
LETMD1 LETM1 domain containing 1
LIF leukemia inhibitory factor
LINC00341 long intergenic non-protein coding RNA 341
LINC00342 long intergenic non-protein coding RNA 342
LRRC15 leucine rich repeat containing 15
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MCOLN3 mucolipin 3
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MNT MAX network transcriptional repressor
N4BP2L1 NEDD4 binding protein 2-like 1
NMRK1 nicotinamide riboside kinase 1
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
OSBPL3 oxysterol binding protein-like 3
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPAP2B phosphatidic acid phosphatase type 2B
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALGDS ral guanine nucleotide dissociation stimulator
RANBP2 RAN binding protein 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RNF144A ring finger protein 144A
RRAGD Ras-related GTP binding D
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
ST18 suppression of tumorigenicity 18, zinc finger
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPP1 tripeptidyl peptidase I
TRAK2 trafficking protein, kinesin binding 2
TXNIP thioredoxin interacting protein
USP34 ubiquitin specific peptidase 34
VAT1 vesicle amine transport 1
ZCCHC6 zinc finger, CCHC domain containing 6
ZNF264 zinc finger protein 264
ZNF292 zinc finger protein 292
ZNF83 zinc finger protein 83
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOC1 apolipoprotein C-I
ARF3 ADP-ribosylation factor 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
C20ORF24 chromosome 20 open reading frame 24
CALR calreticulin
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CKAP4 cytoskeleton-associated protein 4
COL4A5 collagen, type IV, alpha 5
CSRP2 cysteine and glycine-rich protein 2
CTPS1 CTP synthase 1
CTSC cathepsin C
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCXR dicarbonyl/L-xylulose reductase
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP2 epithelial membrane protein 2
FADS2 fatty acid desaturase 2
FBP1 fructose-1,6-bisphosphatase 1
FEN1 flap structure-specific endonuclease 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GSTA1 glutathione S-transferase alpha 1
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICMT isoprenylcysteine carboxyl methyltransferase
IDI1 isopentenyl-diphosphate delta isomerase 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
LMNB1 lamin B1
LRRC17 leucine rich repeat containing 17
LRRC59 leucine rich repeat containing 59
LYZ lysozyme
MARS methionyl-tRNA synthetase
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPZL2 myelin protein zero-like 2
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NEFL neurofilament, light polypeptide
NGRN neugrin, neurite outgrowth associated
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
P4HB prolyl 4-hydroxylase, beta polypeptide
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSAT1 phosphoserine aminotransferase 1
RAD51AP1 RAD51 associated protein 1
REEP1 receptor accessory protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RPN2 ribophorin II
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SESN1 sestrin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SQLE squalene epoxidase
SRGN serglycin
SUB1 SUB1 homolog (S. cerevisiae)
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIP13 thyroid hormone receptor interactor 13
UNC13B unc-13 homolog B (C. elegans)
WARS tryptophanyl-tRNA synthetase
WASF3 WAS protein family, member 3
YARS tyrosyl-tRNA synthetase
ZWINT ZW10 interacting kinetochore protein