BRD-A45498368_WYE-125132_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

230 genes differentially expressed following the BRD-A45498368_WYE-125132_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AGTR1 angiotensin II receptor, type 1
AHNAK2 AHNAK nucleoprotein 2
ARG1 arginase 1
ARMCX1 armadillo repeat containing, X-linked 1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BACE2 beta-site APP-cleaving enzyme 2
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BRD8 bromodomain containing 8
BTG1 B-cell translocation gene 1, anti-proliferative
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CALCOCO1 calcium binding and coiled-coil domain 1
CAMLG calcium modulating ligand
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD99 CD99 molecule
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL18A1 collagen, type XVIII, alpha 1
CSF1R colony stimulating factor 1 receptor
CTSB cathepsin B
CYTH1 cytohesin 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ECHDC2 enoyl CoA hydratase domain containing 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHB2 EPH receptor B2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
F13A1 coagulation factor XIII, A1 polypeptide
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPR137B G protein-coupled receptor 137B
GRN granulin
GSN gelsolin
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IL6ST interleukin 6 signal transducer
INSR insulin receptor
IRS2 insulin receptor substrate 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JADE2 jade family PHD finger 2
JMJD1C jumonji domain containing 1C
KLHDC2 kelch domain containing 2
KLHL21 kelch-like family member 21
LAMP2 lysosomal-associated membrane protein 2
LAPTM5 lysosomal protein transmembrane 5
LEPROT leptin receptor overlapping transcript
LGALS8 lectin, galactoside-binding, soluble, 8
LMBRD1 LMBR1 domain containing 1
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MKNK2 MAP kinase interacting serine/threonine kinase 2
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MTSS1 metastasis suppressor 1
MVP major vault protein
N4BP2L1 NEDD4 binding protein 2-like 1
NBR1 neighbor of BRCA1 gene 1
NEBL nebulette
NMRK1 nicotinamide riboside kinase 1
NOS3 nitric oxide synthase 3 (endothelial cell)
OPTN optineurin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLXNB2 plexin B2
PNKP polynucleotide kinase 3'-phosphatase
PPAP2B phosphatidic acid phosphatase type 2B
PSAP prosaposin
RHOBTB3 Rho-related BTB domain containing 3
RND3 Rho family GTPase 3
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGC Ras-related GTP binding C
RTN2 reticulon 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
SRGN serglycin
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM59 transmembrane protein 59
TPP1 tripeptidyl peptidase I
TSPAN4 tetraspanin 4
TWIST1 twist family bHLH transcription factor 1
VAT1 vesicle amine transport 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AGR2 anterior gradient 2
AK2 adenylate kinase 2
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
BAMBI BMP and activin membrane-bound inhibitor
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW2 basic leucine zipper and W2 domains 2
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CRLF1 cytokine receptor-like factor 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTA cystatin A (stefin A)
CYB561 cytochrome b561
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
DLD dihydrolipoamide dehydrogenase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
ENAH enabled homolog (Drosophila)
ENO1 enolase 1, (alpha)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
GAL galanin/GMAP prepropeptide
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H4C histone cluster 1, H4c
HK2 hexokinase 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LGALS2 lectin, galactoside-binding, soluble, 2
LIMCH1 LIM and calponin homology domains 1
LRRC59 leucine rich repeat containing 59
MALL mal, T-cell differentiation protein-like
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM7 minichromosome maintenance complex component 7
MRPL12 mitochondrial ribosomal protein L12
MTCH2 mitochondrial carrier 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP56 NOP56 ribonucleoprotein
NUP93 nucleoporin 93kDa
NVL nuclear VCP-like
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PYCR1 pyrroline-5-carboxylate reductase 1
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPRR3 small proline-rich protein 3
SRM spermidine synthase
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TIMELESS timeless circadian clock
TMEM45A transmembrane protein 45A
TOX3 TOX high mobility group box family member 3
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
VDAC3 voltage-dependent anion channel 3
WDR77 WD repeat domain 77
XIST X inactive specific transcript (non-protein coding)
ZWINT ZW10 interacting kinetochore protein