BRD-A39996500_radicicol_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

394 genes differentially expressed following the BRD-A39996500_radicicol_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG2 adhesion G protein-coupled receptor G2
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANKMY2 ankyrin repeat and MYND domain containing 2
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATF5 activating transcription factor 5
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BHMT2 betaine--homocysteine S-methyltransferase 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRD2 bromodomain containing 2
C1ORF54 chromosome 1 open reading frame 54
CA2 carbonic anhydrase II
CALR calreticulin
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEMIP cell migration inducing protein, hyaluronan binding
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLDN8 claudin 8
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A5 collagen, type IV, alpha 5
CPVL carboxypeptidase, vitellogenic-like
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CTSB cathepsin B
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DST dystonin
EAPP E2F-associated phosphoprotein
EGF epidermal growth factor
ELF5 E74-like factor 5 (ets domain transcription factor)
EMC3 ER membrane protein complex subunit 3
EMP3 epithelial membrane protein 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
ERO1L ERO1-like (S. cerevisiae)
ERP29 endoplasmic reticulum protein 29
FAM13B family with sequence similarity 13, member B
FASTKD5 FAST kinase domains 5
FBXO7 F-box protein 7
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
FOXJ3 forkhead box J3
FST follistatin
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
G6PD glucose-6-phosphate dehydrogenase
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLIPR1 GLI pathogenesis-related 1
GLUL glutamate-ammonia ligase
GPC3 glypican 3
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IST1 increased sodium tolerance 1 homolog (yeast)
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KLF10 Kruppel-like factor 10
KNG1 kininogen 1
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LBR lamin B receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1A microtubule-associated protein 1A
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
MICB MHC class I polypeptide-related sequence B
MIR22HG MIR22 host gene
MSMO1 methylsterol monooxygenase 1
MSX2 msh homeobox 2
MYO1B myosin IB
MYO5A myosin VA (heavy chain 12, myoxin)
NCOA3 nuclear receptor coactivator 3
NEU1 sialidase 1 (lysosomal sialidase)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOTCH2NL notch 2 N-terminal like
NPC2 Niemann-Pick disease, type C2
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NUCB2 nucleobindin 2
OSER1 oxidative stress responsive serine-rich 1
OXTR oxytocin receptor
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCDH9 protocadherin 9
PCGF1 polycomb group ring finger 1
PDZK1 PDZ domain containing 1
PFDN4 prefoldin subunit 4
PFN2 profilin 2
PIR pirin (iron-binding nuclear protein)
PITX2 paired-like homeodomain 2
PKM pyruvate kinase, muscle
PLIN2 perilipin 2
PLK1 polo-like kinase 1
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRDX2 peroxiredoxin 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PVALB parvalbumin
QPRT quinolinate phosphoribosyltransferase
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RBP1 retinol binding protein 1, cellular
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHOBTB3 Rho-related BTB domain containing 3
RLF rearranged L-myc fusion
RRBP1 ribosome binding protein 1
RYBP RING1 and YY1 binding protein
SC5D sterol-C5-desaturase
SDCBP syndecan binding protein (syntenin)
SEC62 SEC62 homolog (S. cerevisiae)
SECISBP2L SECIS binding protein 2-like
SEPP1 selenoprotein P, plasma, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFTPB surfactant protein B
SFTPD surfactant protein D
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOD1 superoxide dismutase 1, soluble
SORD sorbitol dehydrogenase
SQSTM1 sequestosome 1
STK26 serine/threonine protein kinase 26
SUCO SUN domain containing ossification factor
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDO2 tryptophan 2,3-dioxygenase
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM41B transmembrane protein 41B
TMEM45A transmembrane protein 45A
TNPO1 transportin 1
TOMM34 translocase of outer mitochondrial membrane 34
TSPAN13 tetraspanin 13
TUFT1 tuftelin 1
TUG1 taurine up-regulated 1 (non-protein coding)
UBXN7 UBX domain protein 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WBP5 WW domain binding protein 5
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
AKAP1 A kinase (PRKA) anchor protein 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
APEH acylaminoacyl-peptide hydrolase
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASCC3 activating signal cointegrator 1 complex subunit 3
ASRGL1 asparaginase like 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CA12 carbonic anhydrase XII
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CD93 CD93 molecule
CDC45 cell division cycle 45
CFD complement factor D (adipsin)
CHGB chromogranin B
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CIRBP cold inducible RNA binding protein
CKB creatine kinase, brain
CLDN3 claudin 3
CNN1 calponin 1, basic, smooth muscle
COL10A1 collagen, type X, alpha 1
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CRIP1 cysteine-rich protein 1 (intestinal)
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND2D DENN/MADD domain containing 2D
DES desmin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
DUT deoxyuridine triphosphatase
ECI1 enoyl-CoA delta isomerase 1
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EML3 echinoderm microtubule associated protein like 3
EMP1 epithelial membrane protein 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
F12 coagulation factor XII (Hageman factor)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FAS Fas cell surface death receptor
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FOXG1 forkhead box G1
FRZB frizzled-related protein
FXYD6 FXYD domain containing ion transport regulator 6
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALE UDP-galactose-4-epimerase
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPM6A glycoprotein M6A
GRIA2 glutamate receptor, ionotropic, AMPA 2
HES1 hes family bHLH transcription factor 1
HLF hepatic leukemia factor
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IL1R1 interleukin 1 receptor, type I
IL32 interleukin 32
ILK integrin-linked kinase
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBA inhibin, beta A
INHBB inhibin, beta B
IPO4 importin 4
JAG1 jagged 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KLK10 kallikrein-related peptidase 10
KRT23 keratin 23, type I
KRT81 keratin 81, type II
LAGE3 L antigen family, member 3
LGALS4 lectin, galactoside-binding, soluble, 4
LMCD1 LIM and cysteine-rich domains 1
LPCAT4 lysophosphatidylcholine acyltransferase 4
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC17 leucine rich repeat containing 17
LYZ lysozyme
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCF2L MCF.2 cell line derived transforming sequence-like
MCM4 minichromosome maintenance complex component 4
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
MT2A metallothionein 2A
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NAP1L3 nucleosome assembly protein 1-like 3
NBL1 neuroblastoma 1, DAN family BMP antagonist
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELL2 NEL-like 2 (chicken)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMU neuromedin U
NNMT nicotinamide N-methyltransferase
NREP neuronal regeneration related protein
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
OSBPL10 oxysterol binding protein-like 10
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PALLD palladin, cytoskeletal associated protein
PAQR4 progestin and adipoQ receptor family member IV
PBX1 pre-B-cell leukemia homeobox 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4B phosphodiesterase 4B, cAMP-specific
PDE8B phosphodiesterase 8B
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAT plasminogen activator, tissue
PLN phospholamban
PNMA2 paraneoplastic Ma antigen 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCD protein kinase C, delta
PRKCH protein kinase C, eta
PRSS2 protease, serine, 2 (trypsin 2)
PSIP1 PC4 and SFRS1 interacting protein 1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PVRL3 poliovirus receptor-related 3
PXDN peroxidasin
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN1 regulator of calcineurin 1
RGS13 regulator of G-protein signaling 13
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN1 reticulon 1
SCG2 secretogranin II
SDC1 syndecan 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNAP25 synaptosomal-associated protein, 25kDa
SOD2 superoxide dismutase 2, mitochondrial
SORBS1 sorbin and SH3 domain containing 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SRM spermidine synthase
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
SYNGR3 synaptogyrin 3
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TFDP1 transcription factor Dp-1
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TKTL1 transketolase-like 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TMOD1 tropomodulin 1
TMPRSS3 transmembrane protease, serine 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOX thymocyte selection-associated high mobility group box
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIM22 tripartite motif containing 22
TWF2 twinfilin actin binding protein 2
TYMS thymidylate synthetase
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC1 WAP four-disulfide core domain 1
ZFPM2 zinc finger protein, FOG family member 2