BRD-A39996500_radicicol_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

358 genes differentially expressed following the BRD-A39996500_radicicol_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADI1 acireductone dioxygenase 1
ADM adrenomedullin
AFF1 AF4/FMR2 family, member 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDOC aldolase C, fructose-bisphosphate
AMACR alpha-methylacyl-CoA racemase
APOD apolipoprotein D
ATG4A autophagy related 4A, cysteine peptidase
ATP9A ATPase, class II, type 9A
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPIFA1 BPI fold containing family A, member 1
BTN3A2 butyrophilin, subfamily 3, member A2
C8ORF4 chromosome 8 open reading frame 4
CALCOCO2 calcium binding and coiled-coil domain 2
CBR3 carbonyl reductase 3
CDH3 cadherin 3, type 1, P-cadherin (placental)
CES1 carboxylesterase 1
CGA glycoprotein hormones, alpha polypeptide
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLDN10 claudin 10
CLDN8 claudin 8
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
CPD carboxypeptidase D
CRIPT cysteine-rich PDZ-binding protein
CRYZ crystallin, zeta (quinone reductase)
CSRP2 cysteine and glycine-rich protein 2
CYB5R1 cytochrome b5 reductase 1
CYB5R2 cytochrome b5 reductase 2
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP3 dual specificity phosphatase 3
EAPP E2F-associated phosphoprotein
EGF epidermal growth factor
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
ERO1L ERO1-like (S. cerevisiae)
FADS1 fatty acid desaturase 1
FAM13A family with sequence similarity 13, member A
FHOD3 formin homology 2 domain containing 3
FN1 fibronectin 1
FOXJ3 forkhead box J3
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFNGR1 interferon gamma receptor 1
IGFBP3 insulin-like growth factor binding protein 3
IGKV4-1 immunoglobulin kappa variable 4-1
IL1R2 interleukin 1 receptor, type II
IL6ST interleukin 6 signal transducer
IQGAP1 IQ motif containing GTPase activating protein 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM3A lysine (K)-specific demethylase 3A
KIAA0232 KIAA0232
KLHL24 kelch-like family member 24
LIMCH1 LIM and calponin homology domains 1
LOXL2 lysyl oxidase-like 2
LPAR1 lysophosphatidic acid receptor 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MKRN1 makorin ring finger protein 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NFE2L1 nuclear factor, erythroid 2-like 1
NGRN neugrin, neurite outgrowth associated
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
OBSL1 obscurin-like 1
OSBPL2 oxysterol binding protein-like 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAMR1 peptidase domain containing associated with muscle regeneration 1
PDHX pyruvate dehydrogenase complex, component X
PDZD2 PDZ domain containing 2
PEX11A peroxisomal biogenesis factor 11 alpha
PIEZO2 piezo-type mechanosensitive ion channel component 2
PINK1 PTEN induced putative kinase 1
PIP prolactin-induced protein
PIR pirin (iron-binding nuclear protein)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POPDC3 popeye domain containing 3
PRR4 proline rich 4 (lacrimal)
QPRT quinolinate phosphoribosyltransferase
RANBP2 RAN binding protein 2
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REEP1 receptor accessory protein 1
RGS4 regulator of G-protein signaling 4
RIT1 Ras-like without CAAX 1
RNF114 ring finger protein 114
RPS4Y1 ribosomal protein S4, Y-linked 1
SARAF store-operated calcium entry-associated regulatory factor
SATB1 SATB homeobox 1
SCARB2 scavenger receptor class B, member 2
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SECISBP2L SECIS binding protein 2-like
SEPT6 septin 6
SERINC1 serine incorporator 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SGK1 serum/glucocorticoid regulated kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SLPI secretory leukocyte peptidase inhibitor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRGN serglycin
STATH statherin
STC1 stanniocalcin 1
STOM stomatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TACC2 transforming, acidic coiled-coil containing protein 2
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TMEM45A transmembrane protein 45A
TMEM87A transmembrane protein 87A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNPO1 transportin 1
TNS1 tensin 1
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UBXN7 UBX domain protein 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTN1 actinin, alpha 1
AEBP1 AE binding protein 1
AKAP12 A kinase (PRKA) anchor protein 12
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
C20ORF27 chromosome 20 open reading frame 27
C2CD5 C2 calcium-dependent domain containing 5
CA2 carbonic anhydrase II
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFS embryonal Fyn-associated substrate
EGR3 early growth response 3
EREG epiregulin
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HDGFRP3 hepatoma-derived growth factor, related protein 3
HELLS helicase, lymphoid-specific
HN1 hematological and neurological expressed 1
HNMT histamine N-methyltransferase
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IL17RB interleukin 17 receptor B
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IPO4 importin 4
IPO5 importin 5
ISG15 ISG15 ubiquitin-like modifier
KANK1 KN motif and ankyrin repeat domains 1
KIAA0101 KIAA0101
KRT23 keratin 23, type I
LAGE3 L antigen family, member 3
LGALS3 lectin, galactoside-binding, soluble, 3
LMNB1 lamin B1
LMNB2 lamin B2
LOXL1 lysyl oxidase-like 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MEX3D mex-3 RNA binding family member D
MMP9 matrix metallopeptidase 9
MRPL15 mitochondrial ribosomal protein L15
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MX1 MX dynamin-like GTPase 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
NBN nibrin
NFIB nuclear factor I/B
NHP2 NHP2 ribonucleoprotein
NMU neuromedin U
NOP16 NOP16 nucleolar protein
NRIP1 nuclear receptor interacting protein 1
OIP5 Opa interacting protein 5
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLSCR1 phospholipid scramblase 1
PNP purine nucleoside phosphorylase
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPARG peroxisome proliferator-activated receptor gamma
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSIP1 PC4 and SFRS1 interacting protein 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAB31 RAB31, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAD51 RAD51 recombinase
RAD51C RAD51 paralog C
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RGS10 regulator of G-protein signaling 10
RNASEH2A ribonuclease H2, subunit A
RPIA ribose 5-phosphate isomerase A
RPL10 ribosomal protein L10
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SCGB1D2 secretoglobin, family 1D, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOX4 SRY (sex determining region Y)-box 4
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
SRSF6 serine/arginine-rich splicing factor 6
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFDP1 transcription factor Dp-1
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TK1 thymidine kinase 1, soluble
TMEM109 transmembrane protein 109
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNC tenascin C
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TYRP1 tyrosinase-related protein 1
VCAN versican
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein