BRD-A39996500_radicicol_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

337 genes differentially expressed following the BRD-A39996500_radicicol_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AKAP8L A kinase (PRKA) anchor protein 8-like
AKAP9 A kinase (PRKA) anchor protein 9
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
ASS1 argininosuccinate synthase 1
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AVPI1 arginine vasopressin-induced 1
BBX bobby sox homolog (Drosophila)
BCAM basal cell adhesion molecule (Lutheran blood group)
C1ORF116 chromosome 1 open reading frame 116
C6ORF48 chromosome 6 open reading frame 48
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAT catalase
CAV2 caveolin 2
CCNG1 cyclin G1
CCNG2 cyclin G2
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDK19 cyclin-dependent kinase 19
CES1 carboxylesterase 1
CFB complement factor B
CGA glycoprotein hormones, alpha polypeptide
CLIC5 chloride intracellular channel 5
COLEC12 collectin sub-family member 12
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CREM cAMP responsive element modulator
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRYAB crystallin, alpha B
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DACH1 dachshund family transcription factor 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSG3 desmoglein 3
DSP desmoplakin
DUSP14 dual specificity phosphatase 14
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNB2 ephrin-B2
EGFL6 EGF-like-domain, multiple 6
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FBN2 fibrillin 2
FOSL2 FOS-like antigen 2
FOXC1 forkhead box C1
FXR1 fragile X mental retardation, autosomal homolog 1
FZD7 frizzled class receptor 7
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS6 growth arrest-specific 6
GBA3 glucosidase, beta, acid 3 (gene/pseudogene)
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HOXC10 homeobox C10
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IGF1R insulin-like growth factor 1 receptor
IRX5 iroquois homeobox 5
JUP junction plakoglobin
KLHL24 kelch-like family member 24
KRT15 keratin 15, type I
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LRRC8D leucine rich repeat containing 8 family, member D
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP7 microtubule-associated protein 7
MAPK13 mitogen-activated protein kinase 13
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MME membrane metallo-endopeptidase
MSMB microseminoprotein, beta-
MUC13 mucin 13, cell surface associated
MXI1 MAX interactor 1, dimerization protein
MYH10 myosin, heavy chain 10, non-muscle
MYLIP myosin regulatory light chain interacting protein
MYO6 myosin VI
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NRIP1 nuclear receptor interacting protein 1
OSBPL9 oxysterol binding protein-like 9
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PERP PERP, TP53 apoptosis effector
PGAP1 post-GPI attachment to proteins 1
PHACTR2 phosphatase and actin regulator 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
POR P450 (cytochrome) oxidoreductase
PRUNE prune exopolyphosphatase
PSD3 pleckstrin and Sec7 domain containing 3
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL31 ribosomal protein L31
RRBP1 ribosome binding protein 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEPP1 selenoprotein P, plasma, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPINT2 serine peptidase inhibitor, Kunitz type, 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STK26 serine/threonine protein kinase 26
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TARP TCR gamma alternate reading frame protein
TBC1D4 TBC1 domain family, member 4
TFF1 trefoil factor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNPO1 transportin 1
TPD52L1 tumor protein D52-like 1
TRIM38 tripartite motif containing 38
TSPYL5 TSPY-like 5
TTC39A tetratricopeptide repeat domain 39A
UBB ubiquitin B
UBR2 ubiquitin protein ligase E3 component n-recognin 2
USH1C Usher syndrome 1C (autosomal recessive, severe)
VAV3 vav 3 guanine nucleotide exchange factor
YPEL5 yippee-like 5 (Drosophila)
ZBTB38 zinc finger and BTB domain containing 38
ZMAT3 zinc finger, matrin-type 3
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
ALOX5 arachidonate 5-lipoxygenase
ASRGL1 asparaginase like 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BRCA1 breast cancer 1, early onset
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C20ORF24 chromosome 20 open reading frame 24
CCDC109B coiled-coil domain containing 109B
CCDC85B coiled-coil domain containing 85B
CCK cholecystokinin
CCNA2 cyclin A2
CCNF cyclin F
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPU centromere protein U
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHL1 cell adhesion molecule L1-like
CHMP4A charged multivesicular body protein 4A
CKLF chemokine-like factor
CLEC2B C-type lectin domain family 2, member B
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
CP ceruloplasmin (ferroxidase)
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CSTA cystatin A (stefin A)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL9 chemokine (C-X-C motif) ligand 9
CYCS cytochrome c, somatic
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DENND5A DENN/MADD domain containing 5A
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUOX2 dual oxidase 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EPHB2 EPH receptor B2
ETV1 ets variant 1
ETV5 ets variant 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6A glycoprotein M6A
GREM1 gremlin 1, DAN family BMP antagonist
GRIA2 glutamate receptor, ionotropic, AMPA 2
H1F0 H1 histone family, member 0
H2AFZ H2A histone family, member Z
HMGN2 high mobility group nucleosomal binding domain 2
HNMT histamine N-methyltransferase
HOPX HOP homeobox
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KLF4 Kruppel-like factor 4 (gut)
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LMCD1 LIM and cysteine-rich domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC100505650 uncharacterized LOC100505650
LRRC17 leucine rich repeat containing 17
LYPD1 LY6/PLAUR domain containing 1
LYST lysosomal trafficking regulator
MAP1B microtubule-associated protein 1B
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MMD monocyte to macrophage differentiation-associated
MMP11 matrix metallopeptidase 11
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MSX1 msh homeobox 1
MXRA5 matrix-remodelling associated 5
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NDP Norrie disease (pseudoglioma)
NFIB nuclear factor I/B
NID1 nidogen 1
NPY neuropeptide Y
NREP neuronal regeneration related protein
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
OIP5 Opa interacting protein 5
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMP22 peripheral myelin protein 22
PNMA2 paraneoplastic Ma antigen 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPAP2C phosphatidic acid phosphatase type 2C
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCA protein kinase C, alpha
PRSS3 protease, serine, 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRE protein tyrosine phosphatase, receptor type, E
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RFC4 replication factor C (activator 1) 4, 37kDa
RFTN1 raftlin, lipid raft linker 1
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SATB1 SATB homeobox 1
SCGB2A1 secretoglobin, family 2A, member 1
SDF2L1 stromal cell-derived factor 2-like 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SSBP2 single-stranded DNA binding protein 2
TACC1 transforming, acidic coiled-coil containing protein 1
TCL1A T-cell leukemia/lymphoma 1A
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TIPIN TIMELESS interacting protein
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM223 transmembrane protein 223
TMEM251 transmembrane protein 251
TMX1 thioredoxin-related transmembrane protein 1
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRAPPC4 trafficking protein particle complex 4
TRIB3 tribbles pseudokinase 3
TRMT5 tRNA methyltransferase 5
TSPAN8 tetraspanin 8
TUBA4A tubulin, alpha 4a
TYRP1 tyrosinase-related protein 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UPP1 uridine phosphorylase 1
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
WARS tryptophanyl-tRNA synthetase
WNT5A wingless-type MMTV integration site family, member 5A
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZWINT ZW10 interacting kinetochore protein