BRD-A39093044_K784-3187_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

219 genes differentially expressed following the BRD-A39093044_K784-3187_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
ANKRD12 ankyrin repeat domain 12
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BMP2 bone morphogenetic protein 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP1B charged multivesicular body protein 1B
COL9A2 collagen, type IX, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EIF1 eukaryotic translation initiation factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPAS1 endothelial PAS domain protein 1
FAM13A family with sequence similarity 13, member A
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRMD4B FERM domain containing 4B
FTH1 ferritin, heavy polypeptide 1
FZD10 frizzled class receptor 10
GABARAPL1 GABA(A) receptor-associated protein like 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA1 high mobility group AT-hook 1
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGKV1-5 immunoglobulin kappa variable 1-5
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LARP6 La ribonucleoprotein domain family, member 6
LGALS8 lectin, galactoside-binding, soluble, 8
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MLF1 myeloid leukemia factor 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MXI1 MAX interactor 1, dimerization protein
MYO10 myosin X
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE8A phosphodiesterase 8A
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNF167 ring finger protein 167
RNMT RNA (guanine-7-) methyltransferase
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TGFA transforming growth factor, alpha
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP3 ubiquitin specific peptidase 3
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZNF292 zinc finger protein 292
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABHD10 abhydrolase domain containing 10
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B3GNT1
BEX1 brain expressed, X-linked 1
CALD1 caldesmon 1
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CCNF cyclin F
CCR7 chemokine (C-C motif) receptor 7
CD59 CD59 molecule, complement regulatory protein
COASY CoA synthase
COG2 component of oligomeric golgi complex 2
COL1A1 collagen, type I, alpha 1
CYB5A cytochrome b5 type A (microsomal)
DAPK1 death-associated protein kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
ECI2 enoyl-CoA delta isomerase 2
EED embryonic ectoderm development
ERBB2 erb-b2 receptor tyrosine kinase 2
FUCA1 fucosidase, alpha-L- 1, tissue
FZD2 frizzled class receptor 2
FZD7 frizzled class receptor 7
GAS2L1 growth arrest-specific 2 like 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
HOXA10 homeobox A10
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL27RA interleukin 27 receptor, alpha
JADE2 jade family PHD finger 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LEPROTL1 leptin receptor overlapping transcript-like 1
MAGED1 melanoma antigen family D1
MFSD5 major facilitator superfamily domain containing 5
MGP matrix Gla protein
MRPL15 mitochondrial ribosomal protein L15
MYH10 myosin, heavy chain 10, non-muscle
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY1R neuropeptide Y receptor Y1
NUDCD3 NudC domain containing 3
PCCA propionyl CoA carboxylase, alpha polypeptide
PDGFD platelet derived growth factor D
PEX11B peroxisomal biogenesis factor 11 beta
PHB prohibitin
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
PRSS23 protease, serine, 23
RAD51C RAD51 paralog C
RBM34 RNA binding motif protein 34
RRAGA Ras-related GTP binding A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
SCEL sciellin
SEPHS1 selenophosphate synthetase 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D4 TBC1 domain family, member 4
TCF4 transcription factor 4
THY1 Thy-1 cell surface antigen
TRAPPC4 trafficking protein particle complex 4
UMPS uridine monophosphate synthetase
VCAM1 vascular cell adhesion molecule 1
VCAN versican
WBP1L WW domain binding protein 1-like
ZBTB18 zinc finger and BTB domain containing 18
ZNF652 zinc finger protein 652