BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

254 genes differentially expressed following the BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ARC activity-regulated cytoskeleton-associated protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CALCA calcitonin-related polypeptide alpha
CARS cysteinyl-tRNA synthetase
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CLEC5A C-type lectin domain family 5, member A
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
ENO1 enolase 1, (alpha)
EZR ezrin
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GPC4 glypican 4
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUND jun D proto-oncogene
JUP junction plakoglobin
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KLK10 kallikrein-related peptidase 10
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LRRC15 leucine rich repeat containing 15
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEG3 maternally expressed 3 (non-protein coding)
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MT1G metallothionein 1G
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NKX2-1 NK2 homeobox 1
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
ODC1 ornithine decarboxylase 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OSER1 oxidative stress responsive serine-rich 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRO protein tyrosine phosphatase, receptor type, O
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RPL10 ribosomal protein L10
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD5 SET domain containing 5
SFTPB surfactant protein B
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TICAM1 toll-like receptor adaptor molecule 1
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D3 TSC22 domain family, member 3
TSPYL2 TSPY-like 2
TUBB2B tubulin, beta 2B class IIb
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UBXN7 UBX domain protein 7
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABHD10 abhydrolase domain containing 10
ACPP acid phosphatase, prostate
ADAM10 ADAM metallopeptidase domain 10
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AP5M1 adaptor-related protein complex 5, mu 1 subunit
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASRGL1 asparaginase like 1
ATMIN ATM interactor
B3GNT1
BTBD3 BTB (POZ) domain containing 3
C4ORF27 chromosome 4 open reading frame 27
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CDC20 cell division cycle 20
COG2 component of oligomeric golgi complex 2
CP ceruloplasmin (ferroxidase)
CPD carboxypeptidase D
DAAM1 dishevelled associated activator of morphogenesis 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DLD dihydrolipoamide dehydrogenase
DNAAF2 dynein, axonemal, assembly factor 2
EFR3A EFR3 homolog A (S. cerevisiae)
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB2 erb-b2 receptor tyrosine kinase 2
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FANCF Fanconi anemia, complementation group F
FBXO3 F-box protein 3
FBXO9 F-box protein 9
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FXYD2 FXYD domain containing ion transport regulator 2
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA2 GATA binding protein 2
GHR growth hormone receptor
GLRX glutaredoxin (thioltransferase)
GPER1 G protein-coupled estrogen receptor 1
HOXA10 homeobox A10
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KRT7 keratin 7, type II
LDB2 LIM domain binding 2
LTF lactotransferrin
LYPLA1 lysophospholipase I
LYZ lysozyme
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOA monoamine oxidase A
MCM3 minichromosome maintenance complex component 3
MGP matrix Gla protein
MKKS McKusick-Kaufman syndrome
MMP7 matrix metallopeptidase 7
MRPL15 mitochondrial ribosomal protein L15
MRPL39 mitochondrial ribosomal protein L39
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NOTCH2 notch 2
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
OPN3 opsin 3
PDE9A phosphodiesterase 9A
PDZK1IP1 PDZK1 interacting protein 1
PEX11A peroxisomal biogenesis factor 11 alpha
PHB prohibitin
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLK2 polo-like kinase 2
PLN phospholamban
PON2 paraoxonase 2
PPA2 pyrophosphatase (inorganic) 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PSCA prostate stem cell antigen
RAB2A RAB2A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
REXO2 RNA exonuclease 2
RHOBTB3 Rho-related BTB domain containing 3
RHOT1 ras homolog family member T1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMX1 thioredoxin-related transmembrane protein 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM1 tropomyosin 1 (alpha)
TRAK2 trafficking protein, kinesin binding 2
TRIB1 tribbles pseudokinase 1
TSPAN12 tetraspanin 12
UNC50 unc-50 homolog (C. elegans)
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
UROD uroporphyrinogen decarboxylase
ZMPSTE24 zinc metallopeptidase STE24