BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

192 genes differentially expressed following the BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AREG amphiregulin
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BMP7 bone morphogenetic protein 7
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CBS cystathionine-beta-synthase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRELD2 cysteine-rich with EGF-like domains 2
CXCL2 chemokine (C-X-C motif) ligand 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DSC2 desmocollin 2
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM110B family with sequence similarity 110, member B
FAM46A family with sequence similarity 46, member A
FZD10 frizzled class receptor 10
GAS6 growth arrest-specific 6
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GREM1 gremlin 1, DAN family BMP antagonist
HMOX1 heme oxygenase 1
IGFBP3 insulin-like growth factor binding protein 3
IGHMBP2 immunoglobulin mu binding protein 2
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KTN1 kinectin 1 (kinesin receptor)
LCN2 lipocalin 2
LRP10 low density lipoprotein receptor-related protein 10
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP3 matrix metallopeptidase 3
MPPED2 metallophosphoesterase domain containing 2
MT1M metallothionein 1M
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMRK1 nicotinamide riboside kinase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
OLFM4 olfactomedin 4
P3H2 prolyl 3-hydroxylase 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDIA3 protein disulfide isomerase family A, member 3
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPAP2B phosphatidic acid phosphatase type 2B
PRRC2C proline-rich coiled-coil 2C
RAB6A RAB6A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RGCC regulator of cell cycle
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SARS seryl-tRNA synthetase
SLC16A6 solute carrier family 16, member 6
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
TAC1 tachykinin, precursor 1
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
WNT5B wingless-type MMTV integration site family, member 5B
XPOT exportin, tRNA

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
AKAP12 A kinase (PRKA) anchor protein 12
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BAG3 BCL2-associated athanogene 3
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BST2 bone marrow stromal cell antigen 2
C1QBP complement component 1, q subcomponent binding protein
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CANT1 calcium activated nucleotidase 1
CD200 CD200 molecule
CD93 CD93 molecule
CDK1 cyclin-dependent kinase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COL5A2 collagen, type V, alpha 2
CRYZ crystallin, zeta (quinone reductase)
CTSH cathepsin H
DDB2 damage-specific DNA binding protein 2, 48kDa
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETV1 ets variant 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
GZMK granzyme K (granzyme 3; tryptase II)
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HOXA10 homeobox A10
HOXC6 homeobox C6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM2 interferon induced transmembrane protein 2
IGFBP7 insulin-like growth factor binding protein 7
IL1B interleukin 1, beta
IRF8 interferon regulatory factor 8
KIAA0101 KIAA0101
LAMB1 laminin, beta 1
LAT2 linker for activation of T cells family, member 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO2 LIM domain only 2 (rhombotin-like 1)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKSL1 MARCKS-like 1
MCM6 minichromosome maintenance complex component 6
MX2 MX dynamin-like GTPase 2
MYOF myoferlin
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
PAIP1 poly(A) binding protein interacting protein 1
PLAC8 placenta-specific 8
PNMA2 paraneoplastic Ma antigen 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRKCH protein kinase C, eta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
S100A4 S100 calcium binding protein A4
SEPHS1 selenophosphate synthetase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
STMN1 stathmin 1
STS steroid sulfatase (microsomal), isozyme S
SUB1 SUB1 homolog (S. cerevisiae)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM22 tripartite motif containing 22
TRIP6 thyroid hormone receptor interactor 6
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TYMS thymidylate synthetase
VAMP5 vesicle-associated membrane protein 5
VCAN versican
WEE1 WEE1 G2 checkpoint kinase
ZNF217 zinc finger protein 217