BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

176 genes differentially expressed following the BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AREG amphiregulin
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BMP7 bone morphogenetic protein 7
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRD4 bromodomain containing 4
CBS cystathionine-beta-synthase
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CTTN cortactin
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EMC3 ER membrane protein complex subunit 3
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
G6PD glucose-6-phosphate dehydrogenase
GAA glucosidase, alpha; acid
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GPI glucose-6-phosphate isomerase
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IER5 immediate early response 5
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KLF5 Kruppel-like factor 5 (intestinal)
KRT6A keratin 6A, type II
KTN1 kinectin 1 (kinesin receptor)
LAMP3 lysosomal-associated membrane protein 3
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM4 olfactomedin 4
PCDH9 protocadherin 9
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDGFA platelet-derived growth factor alpha polypeptide
PGLS 6-phosphogluconolactonase
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PPAP2B phosphatidic acid phosphatase type 2B
PTN pleiotrophin
PTX3 pentraxin 3, long
RAP1GAP RAP1 GTPase activating protein
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCRIB scribbled planar cell polarity protein
SDC4 syndecan 4
SFN stratifin
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SQSTM1 sequestosome 1
TALDO1 transaldolase 1
TBX3 T-box 3
TFE3 transcription factor binding to IGHM enhancer 3
THBD thrombomodulin
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDR45 WD repeat domain 45
ZIC1 Zic family member 1
ZNF91 zinc finger protein 91
ZYX zyxin

decreased expression

Symbol Name
AGR2 anterior gradient 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMT1 acidic residue methyltransferase 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
CA12 carbonic anhydrase XII
CA9 carbonic anhydrase IX
CCNA2 cyclin A2
CD200 CD200 molecule
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A2 collagen, type I, alpha 2
CYB5A cytochrome b5 type A (microsomal)
DEPTOR DEP domain containing MTOR-interacting protein
DHFR dihydrofolate reductase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELOVL6 ELOVL fatty acid elongase 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
FLNB filamin B, beta
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLRX glutaredoxin (thioltransferase)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
LOC100505650 uncharacterized LOC100505650
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MBP myelin basic protein
MGP matrix Gla protein
MPC2 mitochondrial pyruvate carrier 2
MSH6 mutS homolog 6
MUC1 mucin 1, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
NAP1L1 nucleosome assembly protein 1-like 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCNA proliferating cell nuclear antigen
PDZK1 PDZ domain containing 1
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRSS23 protease, serine, 23
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAB25 RAB25, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFC2 replication factor C (activator 1) 2, 40kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOB ras homolog family member B
SCP2 sterol carrier protein 2
SIAH2 siah E3 ubiquitin protein ligase 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPDEF SAM pointed domain containing ETS transcription factor
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TXNIP thioredoxin interacting protein
TYMS thymidylate synthetase
UGCG UDP-glucose ceramide glucosyltransferase
XBP1 X-box binding protein 1