BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

322 genes differentially expressed following the BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
AKAP13 A kinase (PRKA) anchor protein 13
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMDHD2 amidohydrolase domain containing 2
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BAG3 BCL2-associated athanogene 3
BDKRB2 bradykinin receptor B2
BEX4 brain expressed, X-linked 4
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CBR3 carbonyl reductase 3
CCL8 chemokine (C-C motif) ligand 8
CD163 CD163 molecule
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSL cathepsin L
DDIT3 DNA-damage-inducible transcript 3
DEFA4 defensin, alpha 4, corticostatin
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
DST dystonin
DUSP5 dual specificity phosphatase 5
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
EZR ezrin
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCLC glutamate-cysteine ligase, catalytic subunit
GPC1 glypican 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGF2R insulin-like growth factor 2 receptor
IGFBP6 insulin-like growth factor binding protein 6
IL1R1 interleukin 1 receptor, type I
INHBB inhibin, beta B
INSR insulin receptor
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LAMB3 laminin, beta 3
LGALS3 lectin, galactoside-binding, soluble, 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MIR22HG MIR22 host gene
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MT1M metallothionein 1M
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGRN neugrin, neurite outgrowth associated
NMRK1 nicotinamide riboside kinase 1
NPC1 Niemann-Pick disease, type C1
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUCB2 nucleobindin 2
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
OSBPL1A oxysterol binding protein-like 1A
PBX3 pre-B-cell leukemia homeobox 3
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PI3 peptidase inhibitor 3, skin-derived
PPAP2B phosphatidic acid phosphatase type 2B
PTN pleiotrophin
RGCC regulator of cell cycle
RRAGC Ras-related GTP binding C
RRBP1 ribosome binding protein 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC16A6 solute carrier family 16, member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SMOX spermine oxidase
SNAI2 snail family zinc finger 2
SPARCL1 SPARC-like 1 (hevin)
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
SYNM synemin, intermediate filament protein
TACC2 transforming, acidic coiled-coil containing protein 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS4 thrombospondin 4
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM41B transmembrane protein 41B
TPP1 tripeptidyl peptidase I
TRIM36 tripartite motif containing 36
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
ZNF165 zinc finger protein 165
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ACSF2 acyl-CoA synthetase family member 2
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5 arachidonate 5-lipoxygenase
AMD1 adenosylmethionine decarboxylase 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASF1B anti-silencing function 1B histone chaperone
ATF1 activating transcription factor 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AURKA aurora kinase A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
C2CD5 C2 calcium-dependent domain containing 5
CCNA2 cyclin A2
CCNF cyclin F
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPU centromere protein U
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CRIP1 cysteine-rich protein 1 (intestinal)
CRYZ crystallin, zeta (quinone reductase)
CTPS1 CTP synthase 1
CTSH cathepsin H
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND2D DENN/MADD domain containing 2D
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EED embryonic ectoderm development
EIF4E eukaryotic translation initiation factor 4E
ELAVL1 ELAV like RNA binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM111A family with sequence similarity 111, member A
FAM13A family with sequence similarity 13, member A
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA2 GATA binding protein 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLUD1 glutamate dehydrogenase 1
GMDS GDP-mannose 4,6-dehydratase
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GRSF1 G-rich RNA sequence binding factor 1
GTF2H5 general transcription factor IIH, polypeptide 5
HADH hydroxyacyl-CoA dehydrogenase
HAUS4 HAUS augmin-like complex, subunit 4
HIST1H4C histone cluster 1, H4c
HMGN3 high mobility group nucleosomal binding domain 3
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LOXL1 lysyl oxidase-like 1
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTA4H leukotriene A4 hydrolase
LY75 lymphocyte antigen 75
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MGST2 microsomal glutathione S-transferase 2
MKI67 marker of proliferation Ki-67
MRPL42 mitochondrial ribosomal protein L42
MRPS35 mitochondrial ribosomal protein S35
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYCBP MYC binding protein
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNT nicotinamide nucleotide transhydrogenase
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NSL1 NSL1, MIS12 kinetochore complex component
NUP210 nucleoporin 210kDa
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCGF2 polycomb group ring finger 2
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PDGFC platelet derived growth factor C
PDLIM5 PDZ and LIM domain 5
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PLSCR1 phospholipid scramblase 1
PON2 paraoxonase 2
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRDX2 peroxiredoxin 2
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCA protein kinase C, alpha
PSIP1 PC4 and SFRS1 interacting protein 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
PUF60 poly-U binding splicing factor 60KDa
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB4A RAB4A, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RBBP4 retinoblastoma binding protein 4
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RPA3 replication protein A3, 14kDa
RPL31 ribosomal protein L31
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAP30 Sin3A-associated protein, 30kDa
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCP2 sterol carrier protein 2
SEPHS1 selenophosphate synthetase 1
SEPT11 septin 11
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC44A4 solute carrier family 44, member 4
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SMC2 structural maintenance of chromosomes 2
SNRPF small nuclear ribonucleoprotein polypeptide F
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TARBP1 TAR (HIV-1) RNA binding protein 1
TFF3 trefoil factor 3 (intestinal)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM109 transmembrane protein 109
TMEM14A transmembrane protein 14A
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIM14 tripartite motif containing 14
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
USP1 ubiquitin specific peptidase 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
VRK1 vaccinia related kinase 1
WFDC2 WAP four-disulfide core domain 2