BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABHD6 abhydrolase domain containing 6
ADM adrenomedullin
ARMCX3 armadillo repeat containing, X-linked 3
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BGN biglycan
BLNK B-cell linker
BTG3 BTG family, member 3
C1QA complement component 1, q subcomponent, A chain
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSG3 desmoglein 3
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EGR1 early growth response 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
FSD1 fibronectin type III and SPRY domain containing 1
GAGE3 G antigen 3
GNAS GNAS complex locus
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KRT6B keratin 6B, type II
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MFAP2 microfibrillar-associated protein 2
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
MZB1 marginal zone B and B1 cell-specific protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
OLFML2A olfactomedin-like 2A
PELI1 pellino E3 ubiquitin protein ligase 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RGS5 regulator of G-protein signaling 5
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SOD2 superoxide dismutase 2, mitochondrial
SOX11 SRY (sex determining region Y)-box 11
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TMEM255A transmembrane protein 255A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D3 TSC22 domain family, member 3
UFM1 ubiquitin-fold modifier 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA7 annexin A7
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARMCX2 armadillo repeat containing, X-linked 2
AURKA aurora kinase A
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CFH complement factor H
CHIC2 cysteine-rich hydrophobic domain 2
COG2 component of oligomeric golgi complex 2
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CTSC cathepsin C
CXADR coxsackie virus and adenovirus receptor
DDB2 damage-specific DNA binding protein 2, 48kDa
DUSP6 dual specificity phosphatase 6
EED embryonic ectoderm development
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPX1 glutathione peroxidase 1
HEBP1 heme binding protein 1
IGFBP4 insulin-like growth factor binding protein 4
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0485 uncharacterized LOC57235
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LUM lumican
LXN latexin
MAPK13 mitogen-activated protein kinase 13
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MBOAT7 membrane bound O-acyltransferase domain containing 7
MMD monocyte to macrophage differentiation-associated
MSH6 mutS homolog 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOTCH2 notch 2
NRIP1 nuclear receptor interacting protein 1
OXSR1 oxidative stress responsive 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCTP phosphatidylcholine transfer protein
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
PPAT phosphoribosyl pyrophosphate amidotransferase
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTGES prostaglandin E synthase
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PURA purine-rich element binding protein A
QDPR quinoid dihydropteridine reductase
RAB4A RAB4A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELN reelin
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RPL39L ribosomal protein L39-like
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORBS1 sorbin and SH3 domain containing 1
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STOM stomatin
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TPD52L1 tumor protein D52-like 1
VCAN versican
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WFDC2 WAP four-disulfide core domain 2
ZBTB18 zinc finger and BTB domain containing 18
ZNF652 zinc finger protein 652