BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP9 A kinase (PRKA) anchor protein 9
AMDHD2 amidohydrolase domain containing 2
APOE apolipoprotein E
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BHLHE40 basic helix-loop-helix family, member e40
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CGA glycoprotein hormones, alpha polypeptide
CLGN calmegin
CLU clusterin
COMP cartilage oligomeric matrix protein
CRISP3 cysteine-rich secretory protein 3
CTTN cortactin
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R1 cytochrome b5 reductase 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENO2 enolase 2 (gamma, neuronal)
FGG fibrinogen gamma chain
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
GAB2 GRB2-associated binding protein 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GARS glycyl-tRNA synthetase
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUND jun D proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KTN1 kinectin 1 (kinesin receptor)
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFSD10 major facilitator superfamily domain containing 10
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PABPN1 poly(A) binding protein, nuclear 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PER1 period circadian clock 1
PILRB paired immunoglobin-like type 2 receptor beta
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAP1GAP RAP1 GTPase activating protein
RBP4 retinol binding protein 4, plasma
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RRAGD Ras-related GTP binding D
RSRC2 arginine/serine-rich coiled-coil 2
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC16A6 solute carrier family 16, member 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
SYT1 synaptotagmin I
TFE3 transcription factor binding to IGHM enhancer 3
TREM1 triggering receptor expressed on myeloid cells 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
WDR45 WD repeat domain 45
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AIM1 absent in melanoma 1
ASF1A anti-silencing function 1A histone chaperone
BAG5 BCL2-associated athanogene 5
BCHE butyrylcholinesterase
C1ORF116 chromosome 1 open reading frame 116
C6ORF62 chromosome 6 open reading frame 62
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CD200 CD200 molecule
CDCA4 cell division cycle associated 4
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEP68 centrosomal protein 68kDa
CKB creatine kinase, brain
COL1A2 collagen, type I, alpha 2
COX11 COX11 cytochrome c oxidase copper chaperone
CTSS cathepsin S
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EMX2 empty spiracles homeobox 2
EPN2 epsin 2
FAM107A family with sequence similarity 107, member A
FANCF Fanconi anemia, complementation group F
FHL1 four and a half LIM domains 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
HES1 hes family bHLH transcription factor 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL1RAP interleukin 1 receptor accessory protein
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
IRF8 interferon regulatory factor 8
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KIAA0485 uncharacterized LOC57235
KLF10 Kruppel-like factor 10
KRT7 keratin 7, type II
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
LOC100505650 uncharacterized LOC100505650
LRRC17 leucine rich repeat containing 17
LYZ lysozyme
MRPL15 mitochondrial ribosomal protein L15
MRPL3 mitochondrial ribosomal protein L3
MSH6 mutS homolog 6
NDN necdin, melanoma antigen (MAGE) family member
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NLRP2 NLR family, pyrin domain containing 2
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NRIP1 nuclear receptor interacting protein 1
PA2G4 proliferation-associated 2G4, 38kDa
PCCB propionyl CoA carboxylase, beta polypeptide
PLN phospholamban
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB4A RAB4A, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SALL2 spalt-like transcription factor 2
SEPHS1 selenophosphate synthetase 1
SOX11 SRY (sex determining region Y)-box 11
STARD7 StAR-related lipid transfer (START) domain containing 7
SUMO3 small ubiquitin-like modifier 3
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
TMEM14B transmembrane protein 14B
TSPAN12 tetraspanin 12
TYRP1 tyrosinase-related protein 1
UBE3C ubiquitin protein ligase E3C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)