BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ANK2 ankyrin 2, neuronal
AQP9 aquaporin 9
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BMP2 bone morphogenetic protein 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLGN calmegin
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRISP3 cysteine-rich secretory protein 3
CTSB cathepsin B
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
INSR insulin receptor
JAG1 jagged 1
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
LGALS4 lectin, galactoside-binding, soluble, 4
MMP19 matrix metallopeptidase 19
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
NCAM1 neural cell adhesion molecule 1
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PANX1 pannexin 1
PBX3 pre-B-cell leukemia homeobox 3
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PTX3 pentraxin 3, long
SCG2 secretogranin II
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLN sarcolipin
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STC1 stanniocalcin 1
STX3 syntaxin 3
THBS4 thrombospondin 4
TPP1 tripeptidyl peptidase I
TRDV3 T cell receptor delta variable 3
TREM1 triggering receptor expressed on myeloid cells 1
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADI1 acireductone dioxygenase 1
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ANXA1 annexin A1
APOC1 apolipoprotein C-I
ASPH aspartate beta-hydroxylase
AURKA aurora kinase A
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND3 cyclin D3
CD58 CD58 molecule
CDC42 cell division cycle 42
CDKN3 cyclin-dependent kinase inhibitor 3
CENPN centromere protein N
CLU clusterin
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COG2 component of oligomeric golgi complex 2
CP ceruloplasmin (ferroxidase)
CRIP1 cysteine-rich protein 1 (intestinal)
CRYM crystallin, mu
CX3CL1 chemokine (C-X3-C motif) ligand 1
CYB5A cytochrome b5 type A (microsomal)
CYBA cytochrome b-245, alpha polypeptide
DCK deoxycytidine kinase
DLD dihydrolipoamide dehydrogenase
EAPP E2F-associated phosphoprotein
FSTL1 follistatin-like 1
FXYD2 FXYD domain containing ion transport regulator 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GSTA4 glutathione S-transferase alpha 4
GTF2H5 general transcription factor IIH, polypeptide 5
HADH hydroxyacyl-CoA dehydrogenase
HAT1 histone acetyltransferase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM2 interferon induced transmembrane protein 2
IGFBP3 insulin-like growth factor binding protein 3
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIF20A kinesin family member 20A
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LXN latexin
MARCKSL1 MARCKS-like 1
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MMP7 matrix metallopeptidase 7
MYH10 myosin, heavy chain 10, non-muscle
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUP37 nucleoporin 37kDa
PCCB propionyl CoA carboxylase, beta polypeptide
PDLIM5 PDZ and LIM domain 5
PLAT plasminogen activator, tissue
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
PRSS23 protease, serine, 23
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RPA3 replication protein A3, 14kDa
RPL39L ribosomal protein L39-like
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
STAG2 stromal antigen 2
STMN1 stathmin 1
TESC tescalcin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
UPK1B uroplakin 1B
VCAN versican
VRK1 vaccinia related kinase 1