BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

180 genes differentially expressed following the BRD-A39093044_2-[(chloroacetyl)(3-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CALR calreticulin
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLEC2B C-type lectin domain family 2, member B
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CRELD2 cysteine-rich with EGF-like domains 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
DUSP2 dual specificity phosphatase 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EGR3 early growth response 3
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KTN1 kinectin 1 (kinesin receptor)
LAMP3 lysosomal-associated membrane protein 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEG3 maternally expressed 3 (non-protein coding)
MMP10 matrix metallopeptidase 10
MXI1 MAX interactor 1, dimerization protein
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PKP1 plakophilin 1
PLAUR plasminogen activator, urokinase receptor
PLTP phospholipid transfer protein
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RNF167 ring finger protein 167
RRAD Ras-related associated with diabetes
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFTPB surfactant protein B
SFTPC surfactant protein C
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNNT1 troponin T type 1 (skeletal, slow)
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASPH aspartate beta-hydroxylase
ATF1 activating transcription factor 1
AURKA aurora kinase A
AURKB aurora kinase B
BMI1 BMI1 proto-oncogene, polycomb ring finger
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCNA2 cyclin A2
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
COX11 COX11 cytochrome c oxidase copper chaperone
CTSC cathepsin C
CYTL1 cytokine-like 1
DCK deoxycytidine kinase
DUSP6 dual specificity phosphatase 6
EED embryonic ectoderm development
EFR3A EFR3 homolog A (S. cerevisiae)
ERBB3 erb-b2 receptor tyrosine kinase 3
EXOSC4 exosome component 4
FABP4 fatty acid binding protein 4, adipocyte
FAM64A family with sequence similarity 64, member A
FANCF Fanconi anemia, complementation group F
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FASTKD3 FAST kinase domains 3
FEN1 flap structure-specific endonuclease 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
HES1 hes family bHLH transcription factor 1
HIST1H4C histone cluster 1, H4c
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB7 homeobox B7
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IQGAP2 IQ motif containing GTPase activating protein 2
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT18 keratin 18, type I
MAK16 MAK16 homolog (S. cerevisiae)
MET MET proto-oncogene, receptor tyrosine kinase
MGP matrix Gla protein
MYH10 myosin, heavy chain 10, non-muscle
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
OSBPL8 oxysterol binding protein-like 8
PCTP phosphatidylcholine transfer protein
PHB prohibitin
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PROM1 prominin 1
PRSS23 protease, serine, 23
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PTTG1 pituitary tumor-transforming 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEC23A Sec23 homolog A (S. cerevisiae)
SEPHS1 selenophosphate synthetase 1
SLC25A46 solute carrier family 25, member 46
SNRPG small nuclear ribonucleoprotein polypeptide G
SORBS1 sorbin and SH3 domain containing 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF1 serine/arginine-rich splicing factor 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TM9SF2 transmembrane 9 superfamily member 2
TMX1 thioredoxin-related transmembrane protein 1
TMX4 thioredoxin-related transmembrane protein 4
TRAM1 translocation associated membrane protein 1
TRIM14 tripartite motif containing 14
UMPS uridine monophosphate synthetase
VCAN versican
ZNHIT3 zinc finger, HIT-type containing 3