BRD-A38878059_BL-077_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-A38878059_BL-077_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACSL3 acyl-CoA synthetase long-chain family member 3
AKIRIN1 akirin 1
ANKRD10 ankyrin repeat domain 10
ANPEP alanyl (membrane) aminopeptidase
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C6ORF62 chromosome 6 open reading frame 62
CAPG capping protein (actin filament), gelsolin-like
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CFB complement factor B
CLDN3 claudin 3
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DYNLT1 dynein, light chain, Tctex-type 1
EFR3A EFR3 homolog A (S. cerevisiae)
ELOVL5 ELOVL fatty acid elongase 5
F11R F11 receptor
FAM189A2 family with sequence similarity 189, member A2
FERMT2 fermitin family member 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GLRX glutaredoxin (thioltransferase)
GP2 glycoprotein 2 (zymogen granule membrane)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOMER2 homer scaffolding protein 2
IFI30 interferon, gamma-inducible protein 30
IGF1R insulin-like growth factor 1 receptor
KIAA1324 KIAA1324
KLK2 kallikrein-related peptidase 2
KRAS Kirsten rat sarcoma viral oncogene homolog
LDLR low density lipoprotein receptor
LEPROT leptin receptor overlapping transcript
LGMN legumain
LINC00341 long intergenic non-protein coding RNA 341
LPXN leupaxin
MAP7 microtubule-associated protein 7
MEIS2 Meis homeobox 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MSMB microseminoprotein, beta-
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEFH neurofilament, heavy polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NUCB2 nucleobindin 2
PBX3 pre-B-cell leukemia homeobox 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPAP2A phosphatidic acid phosphatase type 2A
PRKCD protein kinase C, delta
RAP1GAP RAP1 GTPase activating protein
RHOBTB3 Rho-related BTB domain containing 3
RTN4 reticulon 4
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC14L2 SEC14-like 2 (S. cerevisiae)
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
TGM4 transglutaminase 4
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM41B transmembrane protein 41B
TP53I3 tumor protein p53 inducible protein 3
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C20ORF27 chromosome 20 open reading frame 27
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CSE1L CSE1 chromosome segregation 1-like (yeast)
DEFB1 defensin, beta 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EMX2 empty spiracles homeobox 2
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBL fibrillarin
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
GPSM2 G-protein signaling modulator 2
GTSE1 G-2 and S-phase expressed 1
HADH hydroxyacyl-CoA dehydrogenase
HEBP1 heme binding protein 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGFBP3 insulin-like growth factor binding protein 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LY6E lymphocyte antigen 6 complex, locus E
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MRPS2 mitochondrial ribosomal protein S2
MTA1 metastasis associated 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAP1L1 nucleosome assembly protein 1-like 1
NFIB nuclear factor I/B
NHP2 NHP2 ribonucleoprotein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NMU neuromedin U
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
OXCT1 3-oxoacid CoA transferase 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRR7 proline rich 7 (synaptic)
PTTG1 pituitary tumor-transforming 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RPA1 replication protein A1, 70kDa
RPL22 ribosomal protein L22
RPL36 ribosomal protein L36
RPS21 ribosomal protein S21
RUVBL2 RuvB-like AAA ATPase 2
SLPI secretory leukocyte peptidase inhibitor
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
ST7 suppression of tumorigenicity 7
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
WNT5A wingless-type MMTV integration site family, member 5A