BRD-A38878059_BL-077_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-A38878059_BL-077_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ARG2 arginase 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CCNG2 cyclin G2
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CLCA4 chloride channel accessory 4
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
EXT1 exostosin glycosyltransferase 1
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FOSL2 FOS-like antigen 2
FZD6 frizzled class receptor 6
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
HLA-E major histocompatibility complex, class I, E
HOXD1 homeobox D1
HYOU1 hypoxia up-regulated 1
IGL immunoglobulin lambda locus
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JAG1 jagged 1
KDM6A lysine (K)-specific demethylase 6A
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT18 keratin 18, type I
LAMP2 lysosomal-associated membrane protein 2
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMO3 LIM domain only 3 (rhombotin-like 2)
LXN latexin
LY96 lymphocyte antigen 96
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP7 matrix metallopeptidase 7
MXI1 MAX interactor 1, dimerization protein
OLFM4 olfactomedin 4
ORC1 origin recognition complex, subunit 1
PCP4 Purkinje cell protein 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PELI1 pellino E3 ubiquitin protein ligase 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SC5D sterol-C5-desaturase
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SFRP1 secreted frizzled-related protein 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
ST18 suppression of tumorigenicity 18, zinc finger
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TBX3 T-box 3
THBS2 thrombospondin 2
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDR45 WD repeat domain 45
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AGR2 anterior gradient 2
AMD1 adenosylmethionine decarboxylase 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARG1 arginase 1
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK6 cyclin-dependent kinase 6
CENPA centromere protein A
COPS7A COP9 signalosome subunit 7A
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EMP3 epithelial membrane protein 3
EVL Enah/Vasp-like
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GAL galanin/GMAP prepropeptide
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLDC glycine dehydrogenase (decarboxylating)
GRWD1 glutamate-rich WD repeat containing 1
GTSE1 G-2 and S-phase expressed 1
HOXC10 homeobox C10
HOXC6 homeobox C6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT10 keratin 10, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
MELK maternal embryonic leucine zipper kinase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV3 neuron navigator 3
NPR3 natriuretic peptide receptor 3
NUP62 nucleoporin 62kDa
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PEBP1 phosphatidylethanolamine binding protein 1
PGC progastricsin (pepsinogen C)
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRMT1 protein arginine methyltransferase 1
PTGES prostaglandin E synthase
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS5 ribosomal protein S5
SEPW1 selenoprotein W, 1
SFN stratifin
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPAG5 sperm associated antigen 5
SPATS2L spermatogenesis associated, serine-rich 2-like
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF4 transcription factor 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1