BRD-A37735495_2-[(chloroacetyl)(4-fluorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-A37735495_2-[(chloroacetyl)(4-fluorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AQP1 aquaporin 1 (Colton blood group)
BAG3 BCL2-associated athanogene 3
BTG3 BTG family, member 3
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLU clusterin
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EIF1 eukaryotic translation initiation factor 1
FAM107A family with sequence similarity 107, member A
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPM6B glycoprotein M6B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
INHBA inhibin, beta A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
LTF lactotransferrin
MAST4 microtubule associated serine/threonine kinase family member 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MXI1 MAX interactor 1, dimerization protein
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRCAM neuronal cell adhesion molecule
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RRAD Ras-related associated with diabetes
S100A2 S100 calcium binding protein A2
SELENBP1 selenium binding protein 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFN stratifin
SFTPC surfactant protein C
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
THBD thrombomodulin
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
VCAM1 vascular cell adhesion molecule 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AIM1 absent in melanoma 1
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGAP29 Rho GTPase activating protein 29
B3GNT1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNF cyclin F
CDCA8 cell division cycle associated 8
CENPA centromere protein A
CTSH cathepsin H
CXCL9 chemokine (C-X-C motif) ligand 9
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGF13 fibroblast growth factor 13
FUBP1 far upstream element (FUSE) binding protein 1
HOXA10 homeobox A10
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KANK1 KN motif and ankyrin repeat domains 1
KIF20A kinesin family member 20A
LGALS1 lectin, galactoside-binding, soluble, 1
MARCKSL1 MARCKS-like 1
MLEC malectin
MSMB microseminoprotein, beta-
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS13 regulator of G-protein signaling 13
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATA20 spermatogenesis associated 20
TCTA T-cell leukemia translocation altered
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
USP22 ubiquitin specific peptidase 22
WEE1 WEE1 G2 checkpoint kinase