BRD-A37735495_2-[(chloroacetyl)(4-fluorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-A37735495_2-[(chloroacetyl)(4-fluorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
ATF3 activating transcription factor 3
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BEX4 brain expressed, X-linked 4
BMP7 bone morphogenetic protein 7
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CADM1 cell adhesion molecule 1
CHIC2 cysteine-rich hydrophobic domain 2
DENND1B DENN/MADD domain containing 1B
DHDDS dehydrodolichyl diphosphate synthase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSC2 desmocollin 2
DSG3 desmoglein 3
DTNA dystrobrevin, alpha
EVI2A ecotropic viral integration site 2A
FXYD6 FXYD domain containing ion transport regulator 6
GMFG glia maturation factor, gamma
HK2 hexokinase 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
MYL9 myosin, light chain 9, regulatory
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLEKHO1 pleckstrin homology domain containing, family O member 1
PTN pleiotrophin
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
SARS seryl-tRNA synthetase
SCG5 secretogranin V
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
AGR2 anterior gradient 2
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNB2 cyclin B2
CCND1 cyclin D1
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
COL6A1 collagen, type VI, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP4 dual specificity phosphatase 4
ERBB2 erb-b2 receptor tyrosine kinase 2
HES1 hes family bHLH transcription factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB2 homeobox B2
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ITGB5 integrin, beta 5
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KLK11 kallikrein-related peptidase 11
KRT10 keratin 10, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LOXL1 lysyl oxidase-like 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
MUC16 mucin 16, cell surface associated
NET1 neuroepithelial cell transforming 1
PBK PDZ binding kinase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRKCD protein kinase C, delta
PRSS23 protease, serine, 23
RGS2 regulator of G-protein signaling 2
S100A4 S100 calcium binding protein A4
SEPT9 septin 9
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SMAD3 SMAD family member 3
SORD sorbitol dehydrogenase
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
UPK1B uroplakin 1B