BRD-A37735495_2-[(chloroacetyl)(4-fluorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-A37735495_2-[(chloroacetyl)(4-fluorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
CBR3 carbonyl reductase 3
CHMP1B charged multivesicular body protein 1B
CLEC11A C-type lectin domain family 11, member A
COL11A1 collagen, type XI, alpha 1
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GULP1 GULP, engulfment adaptor PTB domain containing 1
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
IRS2 insulin receptor substrate 2
KRT13 keratin 13, type I
KRT4 keratin 4, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAUR plasminogen activator, urokinase receptor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGCC regulator of cell cycle
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WNT5A wingless-type MMTV integration site family, member 5A
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ANXA4 annexin A4
ANXA6 annexin A6
APOD apolipoprotein D
ATF5 activating transcription factor 5
BASP1 brain abundant, membrane attached signal protein 1
CCL19 chemokine (C-C motif) ligand 19
CD44 CD44 molecule (Indian blood group)
CDC25B cell division cycle 25B
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLDN3 claudin 3
CPE carboxypeptidase E
CTNND2 catenin (cadherin-associated protein), delta 2
CXCL14 chemokine (C-X-C motif) ligand 14
EPAS1 endothelial PAS domain protein 1
FAIM Fas apoptotic inhibitory molecule
FHL1 four and a half LIM domains 1
GRB7 growth factor receptor-bound protein 7
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
KRAS Kirsten rat sarcoma viral oncogene homolog
LGALS1 lectin, galactoside-binding, soluble, 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MGLL monoglyceride lipase
MLEC malectin
NFIB nuclear factor I/B
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PCDH9 protocadherin 9
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS5 regulator of G-protein signaling 5
SCG2 secretogranin II
SFN stratifin
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUB1 SUB1 homolog (S. cerevisiae)
SYNM synemin, intermediate filament protein
TAGLN2 transgelin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TPBG trophoblast glycoprotein
TYRP1 tyrosinase-related protein 1
ZNF512B zinc finger protein 512B