BRD-A37735495_2-[(chloroacetyl)(4-fluorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-A37735495_2-[(chloroacetyl)(4-fluorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ABHD4 abhydrolase domain containing 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANKRD10 ankyrin repeat domain 10
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
CBR3 carbonyl reductase 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHMP1B charged multivesicular body protein 1B
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
JAG1 jagged 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PTX3 pentraxin 3, long
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
S100A2 S100 calcium binding protein A2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD3 SMAD family member 3
SMOX spermine oxidase
SOX9 SRY (sex determining region Y)-box 9
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQSTM1 sequestosome 1
SS18 synovial sarcoma translocation, chromosome 18
STC2 stanniocalcin 2
THBD thrombomodulin
TMEM176B transmembrane protein 176B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALB albumin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASS1 argininosuccinate synthase 1
B3GNT1
BCHE butyrylcholinesterase
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CD200 CD200 molecule
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
DUSP6 dual specificity phosphatase 6
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
GAL galanin/GMAP prepropeptide
GATA2 GATA binding protein 2
GNAS GNAS complex locus
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HOPX HOP homeobox
LYZ lysozyme
MAOA monoamine oxidase A
MEIS1 Meis homeobox 1
NFE2 nuclear factor, erythroid 2
NRGN neurogranin (protein kinase C substrate, RC3)
PDLIM3 PDZ and LIM domain 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SALL2 spalt-like transcription factor 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SOX4 SRY (sex determining region Y)-box 4
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STK26 serine/threonine protein kinase 26
SYNPO synaptopodin
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TRIB2 tribbles pseudokinase 2