BRD-A37735495_2-[(chloroacetyl)(4-fluorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-A37735495_2-[(chloroacetyl)(4-fluorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
ANGPTL2 angiopoietin-like 2
APOD apolipoprotein D
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
CADM1 cell adhesion molecule 1
CCL4 chemokine (C-C motif) ligand 4
CCND2 cyclin D2
CLEC11A C-type lectin domain family 11, member A
COL11A1 collagen, type XI, alpha 1
COL16A1 collagen, type XVI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CTH cystathionine gamma-lyase
CTSK cathepsin K
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DSP desmoplakin
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EMILIN1 elastin microfibril interfacer 1
FCGBP Fc fragment of IgG binding protein
FMOD fibromodulin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS6 growth arrest-specific 6
GPNMB glycoprotein (transmembrane) nmb
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H3H histone cluster 1, H3h
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTRA1 HtrA serine peptidase 1
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
INSM1 insulinoma-associated 1
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIAA0226L KIAA0226-like
KRT19 keratin 19, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
MYL9 myosin, light chain 9, regulatory
MZB1 marginal zone B and B1 cell-specific protein
NDRG1 N-myc downstream regulated 1
NPC1 Niemann-Pick disease, type C1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
OBSL1 obscurin-like 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PADI2 peptidyl arginine deiminase, type II
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKCI protein kinase C, iota
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PXDN peroxidasin
PXMP2 peroxisomal membrane protein 2, 22kDa
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS1 regulator of G-protein signaling 1
SCG5 secretogranin V
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
ST14 suppression of tumorigenicity 14 (colon carcinoma)
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
TCF4 transcription factor 4
TGFB3 transforming growth factor, beta 3
THBS2 thrombospondin 2
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM45A transmembrane protein 45A
TPBG trophoblast glycoprotein
TRIB1 tribbles pseudokinase 1
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
AKR1C3 aldo-keto reductase family 1, member C3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAMBI BMP and activin membrane-bound inhibitor
BRD3 bromodomain containing 3
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CDC45 cell division cycle 45
CHPT1 choline phosphotransferase 1
CIRBP cold inducible RNA binding protein
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF4B eukaryotic translation initiation factor 4B
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
GATA2 GATA binding protein 2
GRB14 growth factor receptor-bound protein 14
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRWD1 glutamate-rich WD repeat containing 1
HEXIM1 hexamethylene bis-acetamide inducible 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL6ST interleukin 6 signal transducer
KIAA0232 KIAA0232
KRT7 keratin 7, type II
LIMS1 LIM and senescent cell antigen-like domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LY75 lymphocyte antigen 75
LYZ lysozyme
MEGF9 multiple EGF-like-domains 9
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NMI N-myc (and STAT) interactor
NRIP1 nuclear receptor interacting protein 1
PCGF2 polycomb group ring finger 2
PDLIM5 PDZ and LIM domain 5
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKCA protein kinase C, alpha
PRPF4 pre-mRNA processing factor 4
RAB11A RAB11A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOB ras homolog family member B
RPA3 replication protein A3, 14kDa
RPIA ribose 5-phosphate isomerase A
RPL27A ribosomal protein L27a
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SEC23A Sec23 homolog A (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC25A46 solute carrier family 25, member 46
SNRPE small nuclear ribonucleoprotein polypeptide E
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TESC tescalcin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMX4 thioredoxin-related transmembrane protein 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TXNDC9 thioredoxin domain containing 9
UPK1B uroplakin 1B
WFDC2 WAP four-disulfide core domain 2
ZBTB18 zinc finger and BTB domain containing 18
ZNF106 zinc finger protein 106
ZNF185 zinc finger protein 185 (LIM domain)