BRD-A37735495_2-[(chloroacetyl)(4-fluorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-A37735495_2-[(chloroacetyl)(4-fluorophenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLCA1 chloride channel accessory 1
CLDN3 claudin 3
CLDN7 claudin 7
CLU clusterin
CXCL2 chemokine (C-X-C motif) ligand 2
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
ELF5 E74-like factor 5 (ets domain transcription factor)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
F11R F11 receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FCGBP Fc fragment of IgG binding protein
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GLUL glutamate-ammonia ligase
GPER1 G protein-coupled estrogen receptor 1
HDAC9 histone deacetylase 9
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IGHM immunoglobulin heavy constant mu
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
LMO4 LIM domain only 4
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MUC5B mucin 5B, oligomeric mucus/gel-forming
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMRK1 nicotinamide riboside kinase 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PCDH9 protocadherin 9
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG3 paternally expressed 3
PTPRC protein tyrosine phosphatase, receptor type, C
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCG5 secretogranin V
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCF21 transcription factor 21
TFF3 trefoil factor 3 (intestinal)
THBD thrombomodulin
TMEM30B transmembrane protein 30B
TPBG trophoblast glycoprotein
TRIM36 tripartite motif containing 36
TRPS1 trichorhinophalangeal syndrome I
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZG16 zymogen granule protein 16

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTN1 actinin, alpha 1
AHR aryl hydrocarbon receptor
AIM1 absent in melanoma 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALOX5 arachidonate 5-lipoxygenase
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BASP1 brain abundant, membrane attached signal protein 1
C5ORF15 chromosome 5 open reading frame 15
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CBR3 carbonyl reductase 3
CCNF cyclin F
CCNG1 cyclin G1
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD99 CD99 molecule
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COL4A2 collagen, type IV, alpha 2
CTSH cathepsin H
CYTL1 cytokine-like 1
DCT dopachrome tautomerase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ERBB3 erb-b2 receptor tyrosine kinase 3
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP4 fatty acid binding protein 4, adipocyte
FEN1 flap structure-specific endonuclease 1
FLNB filamin B, beta
FSTL1 follistatin-like 1
FXYD2 FXYD domain containing ion transport regulator 2
GNAS GNAS complex locus
GOLM1 golgi membrane protein 1
GPX1 glutathione peroxidase 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXA10 homeobox A10
HOXB6 homeobox B6
HOXB7 homeobox B7
HOXC6 homeobox C6
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGSF3 immunoglobulin superfamily, member 3
IRS2 insulin receptor substrate 2
KRT10 keratin 10, type I
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAT2 linker for activation of T cells family, member 2
LMO2 LIM domain only 2 (rhombotin-like 1)
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MLEC malectin
MRPL33 mitochondrial ribosomal protein L33
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNMT nicotinamide N-methyltransferase
NREP neuronal regeneration related protein
NRN1 neuritin 1
PDLIM2 PDZ and LIM domain 2 (mystique)
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POMZP3 POM121 and ZP3 fusion
PON2 paraoxonase 2
PPARG peroxisome proliferator-activated receptor gamma
PRKCA protein kinase C, alpha
PRKD3 protein kinase D3
PRSS23 protease, serine, 23
QPCT glutaminyl-peptide cyclotransferase
RAB31 RAB31, member RAS oncogene family
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC25A46 solute carrier family 25, member 46
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SYNGR1 synaptogyrin 1
TBC1D16 TBC1 domain family, member 16
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFB2M transcription factor B2, mitochondrial
TLE4 transducin-like enhancer of split 4
TMEM2 transmembrane protein 2
UBE2E1 ubiquitin-conjugating enzyme E2E 1
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18