BRD-A36630025_-666_HEPG2_6.0_h_0.35_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

187 genes differentially expressed following the BRD-A36630025_-666_HEPG2_6.0_h_0.35_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANGPTL2 angiopoietin-like 2
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
ARMCX2 armadillo repeat containing, X-linked 2
ASPN asporin
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CRABP2 cellular retinoic acid binding protein 2
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DERL1 derlin 1
DUSP14 dual specificity phosphatase 14
EFNB2 ephrin-B2
EGLN3 egl-9 family hypoxia-inducible factor 3
EMP1 epithelial membrane protein 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FAM129A family with sequence similarity 129, member A
FASTKD5 FAST kinase domains 5
FLT1 fms-related tyrosine kinase 1
FZD6 frizzled class receptor 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GPNMB glycoprotein (transmembrane) nmb
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXA5 homeobox A5
IGFBP5 insulin-like growth factor binding protein 5
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAPTM5 lysosomal protein transmembrane 5
LUM lumican
LY96 lymphocyte antigen 96
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NLRP2 NLR family, pyrin domain containing 2
OLFML2A olfactomedin-like 2A
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPL periplakin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB25 RAB25, member RAS oncogene family
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SCPEP1 serine carboxypeptidase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPINT2 serine peptidase inhibitor, Kunitz type, 2
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
THBS2 thrombospondin 2
TIGAR TP53 induced glycolysis regulatory phosphatase
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADGRG6 adhesion G protein-coupled receptor G6
AGTR1 angiotensin II receptor, type 1
AHSG alpha-2-HS-glycoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
APOA2 apolipoprotein A-II
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
C8ORF4 chromosome 8 open reading frame 4
CCNA2 cyclin A2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK19 cyclin-dependent kinase 19
CDK7 cyclin-dependent kinase 7
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CKS2 CDC28 protein kinase regulatory subunit 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL2 ELOVL fatty acid elongase 2
FGB fibrinogen beta chain
FGF13 fibroblast growth factor 13
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
GMDS GDP-mannose 4,6-dehydratase
GSPT1 G1 to S phase transition 1
HSPA8 heat shock 70kDa protein 8
IGHM immunoglobulin heavy constant mu
JMJD6 jumonji domain containing 6
KIAA0368 KIAA0368
KPNB1 karyopherin (importin) beta 1
LAMB1 laminin, beta 1
LYRM4 LYR motif containing 4
LYZ lysozyme
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCKSL1 MARCKS-like 1
MAST2 microtubule associated serine/threonine kinase 2
MELK maternal embryonic leucine zipper kinase
MNAT1 MNAT CDK-activating kinase assembly factor 1
MRPS30 mitochondrial ribosomal protein S30
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NR2F2 nuclear receptor subfamily 2, group F, member 2
OXTR oxytocin receptor
PBK PDZ binding kinase
PHACTR2 phosphatase and actin regulator 2
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
QKI QKI, KH domain containing, RNA binding
RAP1GAP RAP1 GTPase activating protein
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
S100P S100 calcium binding protein P
SELENBP1 selenium binding protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STOM stomatin
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYT1 synaptotagmin I
TBC1D4 TBC1 domain family, member 4
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TF transferrin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TRIM14 tripartite motif containing 14
TSPAN8 tetraspanin 8
TXNRD1 thioredoxin reductase 1
UBE3C ubiquitin protein ligase E3C
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
ZFAND5 zinc finger, AN1-type domain 5
ZMYND8 zinc finger, MYND-type containing 8