BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BGN biglycan
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CACYBP calcyclin binding protein
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEMIP cell migration inducing protein, hyaluronan binding
CLDN10 claudin 10
COMP cartilage oligomeric matrix protein
CSRP1 cysteine and glycine-rich protein 1
CTSZ cathepsin Z
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FILIP1L filamin A interacting protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS6 growth arrest-specific 6
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF2 Kruppel-like factor 2
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LRRC15 leucine rich repeat containing 15
MMP10 matrix metallopeptidase 10
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PXDN peroxidasin
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SQLE squalene epoxidase
TMEM2 transmembrane protein 2
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADCY1 adenylate cyclase 1 (brain)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATMIN ATM interactor
B3GNT1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CD24 CD24 molecule
CDC20 cell division cycle 20
CHERP calcium homeostasis endoplasmic reticulum protein
COL4A5 collagen, type IV, alpha 5
CXCL14 chemokine (C-X-C motif) ligand 14
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLRX glutaredoxin (thioltransferase)
GPER1 G protein-coupled estrogen receptor 1
HCP5 HLA complex P5 (non-protein coding)
HLA-F major histocompatibility complex, class I, F
IGFBP6 insulin-like growth factor binding protein 6
KIF20A kinesin family member 20A
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPY neuropeptide Y
OXTR oxytocin receptor
PCNA proliferating cell nuclear antigen
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKCD protein kinase C, delta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTTG1 pituitary tumor-transforming 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBM47 RNA binding motif protein 47
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLPI secretory leukocyte peptidase inhibitor
SRPX sushi-repeat containing protein, X-linked
TARP TCR gamma alternate reading frame protein