BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
AKAP13 A kinase (PRKA) anchor protein 13
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
CACYBP calcyclin binding protein
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHIC2 cysteine-rich hydrophobic domain 2
CRYAB crystallin, alpha B
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45B growth arrest and DNA-damage-inducible, beta
GAREM GRB2 associated, regulator of MAPK1
GAS6 growth arrest-specific 6
GCLM glutamate-cysteine ligase, modifier subunit
GPM6B glycoprotein M6B
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL6 interleukin 6
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
KLF9 Kruppel-like factor 9
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MATN2 matrilin 2
MBOAT7 membrane bound O-acyltransferase domain containing 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP1 matrix metallopeptidase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYO10 myosin X
NDRG1 N-myc downstream regulated 1
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAD Ras-related associated with diabetes
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
TIMP3 TIMP metallopeptidase inhibitor 3
TPPP3 tubulin polymerization-promoting protein family member 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D3 TSC22 domain family, member 3
TUSC3 tumor suppressor candidate 3
UGDH UDP-glucose 6-dehydrogenase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ADIPOQ adiponectin, C1Q and collagen domain containing
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ASPH aspartate beta-hydroxylase
AURKA aurora kinase A
AURKB aurora kinase B
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF2 chromosome 14 open reading frame 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP22 dual specificity phosphatase 22
DUSP4 dual specificity phosphatase 4
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENO1 enolase 1, (alpha)
EREG epiregulin
FXYD5 FXYD domain containing ion transport regulator 5
GDE1 glycerophosphodiester phosphodiesterase 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HIST1H4C histone cluster 1, H4c
HOXA10 homeobox A10
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IL13RA2 interleukin 13 receptor, alpha 2
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MLEC malectin
NADK NAD kinase
NPY neuropeptide Y
OAT ornithine aminotransferase
PBX3 pre-B-cell leukemia homeobox 3
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
PIP prolactin-induced protein
PSRC1 proline/serine-rich coiled-coil 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
USP22 ubiquitin specific peptidase 22