BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

176 genes differentially expressed following the BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMDHD2 amidohydrolase domain containing 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARL4A ADP-ribosylation factor-like 4A
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BTG1 B-cell translocation gene 1, anti-proliferative
CACYBP calcyclin binding protein
CARS cysteinyl-tRNA synthetase
CCDC53 coiled-coil domain containing 53
CCDC59 coiled-coil domain containing 59
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLU clusterin
COL9A3 collagen, type IX, alpha 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTH cystathionine gamma-lyase
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
HACD1 3-hydroxyacyl-CoA dehydratase 1
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
IQCG IQ motif containing G
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
LMO4 LIM domain only 4
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICALL1 MICAL-like 1
MLF1 myeloid leukemia factor 1
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SCYL3 SCY1-like 3 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TRIM38 tripartite motif containing 38
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADGRF5 adhesion G protein-coupled receptor F5
ADI1 acireductone dioxygenase 1
AGTR1 angiotensin II receptor, type 1
AIM1 absent in melanoma 1
ANPEP alanyl (membrane) aminopeptidase
APLP2 amyloid beta (A4) precursor-like protein 2
AQP1 aquaporin 1 (Colton blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
B3GNT1
CCNE2 cyclin E2
CD59 CD59 molecule, complement regulatory protein
CXADR coxsackie virus and adenovirus receptor
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
DPP4 dipeptidyl-peptidase 4
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EPN2 epsin 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FZD6 frizzled class receptor 6
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GREM1 gremlin 1, DAN family BMP antagonist
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOPX HOP homeobox
IGFBP5 insulin-like growth factor binding protein 5
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KANK1 KN motif and ankyrin repeat domains 1
LAMP5 lysosomal-associated membrane protein family, member 5
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMO3 LIM domain only 3 (rhombotin-like 2)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MEIS2 Meis homeobox 2
MLEC malectin
MPPED2 metallophosphoesterase domain containing 2
NFIB nuclear factor I/B
NT5DC2 5'-nucleotidase domain containing 2
PDLIM3 PDZ and LIM domain 3
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
PSRC1 proline/serine-rich coiled-coil 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTTG1 pituitary tumor-transforming 1
REG3A regenerating islet-derived 3 alpha
S100A8 S100 calcium binding protein A8
SDC1 syndecan 1
SDC2 syndecan 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPTBN1 spectrin, beta, non-erythrocytic 1
SRGN serglycin
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
TM4SF1 transmembrane 4 L six family member 1
TMEM164 transmembrane protein 164
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
USP22 ubiquitin specific peptidase 22
VDAC1 voltage-dependent anion channel 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1