BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

444 genes differentially expressed following the BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ACTN1 actinin, alpha 1
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AZU1 azurocidin 1
BCAP31 B-cell receptor-associated protein 31
BMP2 bone morphogenetic protein 2
BMP7 bone morphogenetic protein 7
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAPN2 calpain 2, (m/II) large subunit
CBS cystathionine-beta-synthase
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
CTSL cathepsin L
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R1 cytochrome b5 reductase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSC2 desmocollin 2
DSG3 desmoglein 3
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
ELANE elastase, neutrophil expressed
ELL2 elongation factor, RNA polymerase II, 2
EMC3 ER membrane protein complex subunit 3
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV5 ets variant 5
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FAM134A family with sequence similarity 134, member A
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FSCN1 fascin actin-bundling protein 1
FTH1 ferritin, heavy polypeptide 1
FTL ferritin, light polypeptide
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAREM GRB2 associated, regulator of MAPK1
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPX2 glutathione peroxidase 2
GRB10 growth factor receptor-bound protein 10
GSTP1 glutathione S-transferase pi 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL1R2 interleukin 1 receptor, type II
IL6R interleukin 6 receptor
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JMJD6 jumonji domain containing 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMP1 lysosomal-associated membrane protein 1
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICALL1 MICAL-like 1
MIR22HG MIR22 host gene
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MYO10 myosin X
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NMRK1 nicotinamide riboside kinase 1
NPC1 Niemann-Pick disease, type C1
NRIP3 nuclear receptor interacting protein 3
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDGFA platelet-derived growth factor alpha polypeptide
PERP PERP, TP53 apoptosis effector
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PKP1 plakophilin 1
PLAUR plasminogen activator, urokinase receptor
POPDC3 popeye domain containing 3
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PTN pleiotrophin
RB1CC1 RB1-inducible coiled-coil 1
RGCC regulator of cell cycle
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SFN stratifin
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMOX spermine oxidase
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TFE3 transcription factor binding to IGHM enhancer 3
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TPP1 tripeptidyl peptidase I
TRIB1 tribbles pseudokinase 1
TRIM29 tripartite motif containing 29
TUBB2A tubulin, beta 2A class IIa
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADCY1 adenylate cyclase 1 (brain)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
AKAP7 A kinase (PRKA) anchor protein 7
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMT1 acidic residue methyltransferase 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C2CD5 C2 calcium-dependent domain containing 5
C3 complement component 3
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD200 CD200 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CFI complement factor I
CHEK2 checkpoint kinase 2
CKAP2 cytoskeleton associated protein 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLMN calmin (calponin-like, transmembrane)
CP ceruloplasmin (ferroxidase)
CSAD cysteine sulfinic acid decarboxylase
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DEPTOR DEP domain containing MTOR-interacting protein
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYD dihydropyrimidine dehydrogenase
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
E2F8 E2F transcription factor 8
ELOVL6 ELOVL fatty acid elongase 6
EMP2 epithelial membrane protein 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FANCI Fanconi anemia, complementation group I
FASTKD3 FAST kinase domains 3
FBP1 fructose-1,6-bisphosphatase 1
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FLNB filamin B, beta
FOXM1 forkhead box M1
GATA3 GATA binding protein 3
GEMIN2 gem (nuclear organelle) associated protein 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GREB1 growth regulation by estrogen in breast cancer 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTM3 glutathione S-transferase mu 3 (brain)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNMT histamine N-methyltransferase
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP5 insulin-like growth factor binding protein 5
ISOC1 isochorismatase domain containing 1
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIAA1467 KIAA1467
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MANSC1 MANSC domain containing 1
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MEIS2 Meis homeobox 2
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MPC2 mitochondrial pyruvate carrier 2
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
MYB v-myb avian myeloblastosis viral oncogene homolog
MYCBP MYC binding protein
MYH10 myosin, heavy chain 10, non-muscle
NASP nuclear autoantigenic sperm protein (histone-binding)
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NPY1R neuropeptide Y receptor Y1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NUP210 nucleoporin 210kDa
NUSAP1 nucleolar and spindle associated protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PBX1 pre-B-cell leukemia homeobox 1
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PDHB pyruvate dehydrogenase (lipoamide) beta
PEG10 paternally expressed 10
PEX11A peroxisomal biogenesis factor 11 alpha
PGRMC2 progesterone receptor membrane component 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRC1 protein regulator of cytokinesis 1
PRDX3 peroxiredoxin 3
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PSIP1 PC4 and SFRS1 interacting protein 1
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RAP2C RAP2C, member of RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBPMS RNA binding protein with multiple splicing
RFC3 replication factor C (activator 1) 3, 38kDa
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMSB15B thymosin beta 15B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TROAP trophinin associated protein
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TTK TTK protein kinase
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VCAN versican
VRK1 vaccinia related kinase 1
WEE1 WEE1 G2 checkpoint kinase
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZWINT ZW10 interacting kinetochore protein