BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY2 adenylate cyclase 2 (brain)
ADM adrenomedullin
AEBP1 AE binding protein 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
BAG3 BCL2-associated athanogene 3
C1QA complement component 1, q subcomponent, A chain
CALD1 caldesmon 1
CD84 CD84 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
FGL2 fibrinogen-like 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FTH1 ferritin, heavy polypeptide 1
GAGE3 G antigen 3
GPNMB glycoprotein (transmembrane) nmb
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IL17RB interleukin 17 receptor B
INSR insulin receptor
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KLHL24 kelch-like family member 24
LRRC15 leucine rich repeat containing 15
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFAP5 microfibrillar associated protein 5
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGCC regulator of cell cycle
SEPP1 selenoprotein P, plasma, 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERTAD2 SERTA domain containing 2
SMAD1 SMAD family member 1
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TRDV3 T cell receptor delta variable 3
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
AGTR1 angiotensin II receptor, type 1
AHR aryl hydrocarbon receptor
AIM1 absent in melanoma 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA6 annexin A6
APLP2 amyloid beta (A4) precursor-like protein 2
APOLD1 apolipoprotein L domain containing 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
ATMIN ATM interactor
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
AURKA aurora kinase A
B3GNT1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C2CD5 C2 calcium-dependent domain containing 5
C8ORF4 chromosome 8 open reading frame 4
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP170 centrosomal protein 170kDa
CTSH cathepsin H
CUL4B cullin 4B
DAPK1 death-associated protein kinase 1
DCLK1 doublecortin-like kinase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ERLIN1 ER lipid raft associated 1
ETNK1 ethanolamine kinase 1
FLNB filamin B, beta
FLRT2 fibronectin leucine rich transmembrane protein 2
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GLCE glucuronic acid epimerase
IGFBP4 insulin-like growth factor binding protein 4
IL6ST interleukin 6 signal transducer
IPO5 importin 5
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KCTD12 potassium channel tetramerization domain containing 12
KIAA0100 KIAA0100
LAMB1 laminin, beta 1
LGALS1 lectin, galactoside-binding, soluble, 1
LMNB1 lamin B1
LXN latexin
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MDFIC MyoD family inhibitor domain containing
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGP matrix Gla protein
MLEC malectin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBPF10 neuroblastoma breakpoint family, member 10
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NSF N-ethylmaleimide-sensitive factor
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTCH1 patched 1
RAB11A RAB11A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCAN1 regulator of calcineurin 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RRP1B ribosomal RNA processing 1B
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A4 solute carrier family 16, member 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLK STE20-like kinase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
SSFA2 sperm specific antigen 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMEM47 transmembrane protein 47
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UNC13B unc-13 homolog B (C. elegans)
USP22 ubiquitin specific peptidase 22
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC24 zinc finger, CCHC domain containing 24