BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL9A2 collagen, type IX, alpha 2
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGR1 early growth response 1
FGL2 fibrinogen-like 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD6 FXYD domain containing ion transport regulator 6
GPNMB glycoprotein (transmembrane) nmb
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
JUN jun proto-oncogene
JUND jun D proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
LCN2 lipocalin 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFSD10 major facilitator superfamily domain containing 10
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
NCAM1 neural cell adhesion molecule 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OSBPL1A oxysterol binding protein-like 1A
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG3 paternally expressed 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTN pleiotrophin
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
S100P S100 calcium binding protein P
SPINK4 serine peptidase inhibitor, Kazal type 4
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
B3GNT1
BICD2 bicaudal D homolog 2 (Drosophila)
CBR3 carbonyl reductase 3
CCNF cyclin F
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FZD7 frizzled class receptor 7
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
HOPX HOP homeobox
HOXA5 homeobox A5
HOXC6 homeobox C6
IGFBP6 insulin-like growth factor binding protein 6
JADE2 jade family PHD finger 2
KLHL9 kelch-like family member 9
LAMC1 laminin, gamma 1 (formerly LAMB2)
LASP1 LIM and SH3 protein 1
LOX lysyl oxidase
MET MET proto-oncogene, receptor tyrosine kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLEC malectin
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NISCH nischarin
NNT nicotinamide nucleotide transhydrogenase
OXTR oxytocin receptor
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POSTN periostin, osteoblast specific factor
RBPMS RNA binding protein with multiple splicing
SACS sacsin molecular chaperone
SEC23A Sec23 homolog A (S. cerevisiae)
SELT selenoprotein T
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC25A46 solute carrier family 25, member 46
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D16 TBC1 domain family, member 16
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP4 TIMP metallopeptidase inhibitor 4
TMEM164 transmembrane protein 164
TMX1 thioredoxin-related transmembrane protein 1
TNC tenascin C
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UNC13B unc-13 homolog B (C. elegans)
ZBTB18 zinc finger and BTB domain containing 18