BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

226 genes differentially expressed following the BRD-A36275421_2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ARC activity-regulated cytoskeleton-associated protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CCL4 chemokine (C-C motif) ligand 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN7 claudin 7
CLGN calmegin
CLIC5 chloride intracellular channel 5
CLU clusterin
COL6A2 collagen, type VI, alpha 2
CSRP1 cysteine and glycine-rich protein 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FAM107A family with sequence similarity 107, member A
FMOD fibromodulin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
FXYD6 FXYD domain containing ion transport regulator 6
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GFOD1 glucose-fructose oxidoreductase domain containing 1
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPRASP1 G protein-coupled receptor associated sorting protein 1
HEPH hephaestin
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLK10 kallikrein-related peptidase 10
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT8 keratin 8, type II
KTN1 kinectin 1 (kinesin receptor)
LDLR low density lipoprotein receptor
MATN2 matrilin 2
MEF2C myocyte enhancer factor 2C
MEG3 maternally expressed 3 (non-protein coding)
MEIS1 Meis homeobox 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MT1M metallothionein 1M
MUC16 mucin 16, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYLIP myosin regulatory light chain interacting protein
NDRG1 N-myc downstream regulated 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
PADI2 peptidyl arginine deiminase, type II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCDH17 protocadherin 17
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PLD3 phospholipase D family, member 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RTN1 reticulon 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SIK1 salt-inducible kinase 1
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SPON1 spondin 1, extracellular matrix protein
SSPN sarcospan
SULF1 sulfatase 1
TEK TEK tyrosine kinase, endothelial
TFF3 trefoil factor 3 (intestinal)
TMEM30B transmembrane protein 30B
TNNT1 troponin T type 1 (skeletal, slow)
TOX thymocyte selection-associated high mobility group box
TPBG trophoblast glycoprotein
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AMD1 adenosylmethionine decarboxylase 1
APMAP adipocyte plasma membrane associated protein
ARF4 ADP-ribosylation factor 4
AURKA aurora kinase A
B3GNT1
CCNA2 cyclin A2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDK4 cyclin-dependent kinase 4
CLCN3 chloride channel, voltage-sensitive 3
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
COL4A1 collagen, type IV, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CST3 cystatin C
CTSB cathepsin B
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EIF3B eukaryotic translation initiation factor 3, subunit B
ERBB3 erb-b2 receptor tyrosine kinase 3
ERLIN2 ER lipid raft associated 2
FASTKD5 FAST kinase domains 5
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPX1 glutathione peroxidase 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
JADE2 jade family PHD finger 2
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LINC00341 long intergenic non-protein coding RNA 341
LRRC41 leucine rich repeat containing 41
LYN LYN proto-oncogene, Src family tyrosine kinase
LYZ lysozyme
MACF1 microtubule-actin crosslinking factor 1
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
MLEC malectin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNMT nicotinamide N-methyltransferase
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NREP neuronal regeneration related protein
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PPAT phosphoribosyl pyrophosphate amidotransferase
RAD23B RAD23 homolog B (S. cerevisiae)
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RHOA ras homolog family member A
RRP1B ribosomal RNA processing 1B
SELT selenoprotein T
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTBN1 spectrin, beta, non-erythrocytic 1
SRP72 signal recognition particle 72kDa
SRPX sushi-repeat containing protein, X-linked
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D16 TBC1 domain family, member 16
TCL1A T-cell leukemia/lymphoma 1A
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TM9SF2 transmembrane 9 superfamily member 2
TMEM2 transmembrane protein 2
TMX4 thioredoxin-related transmembrane protein 4
TOP2B topoisomerase (DNA) II beta 180kDa
TSPAN13 tetraspanin 13
TXNDC9 thioredoxin domain containing 9
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UNC119B unc-119 homolog B (C. elegans)
URI1 URI1, prefoldin-like chaperone
USP22 ubiquitin specific peptidase 22
VCAN versican
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF185 zinc finger protein 185 (LIM domain)