BRD-A35869383_ibrutinib_HCC515_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-A35869383_ibrutinib_HCC515_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
CAPN1 calpain 1, (mu/I) large subunit
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
CPD carboxypeptidase D
CSTA cystatin A (stefin A)
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EGFL6 EGF-like-domain, multiple 6
EPB41L1 erythrocyte membrane protein band 4.1-like 1
FASN fatty acid synthase
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
FN1 fibronectin 1
FTH1 ferritin, heavy polypeptide 1
FXYD2 FXYD domain containing ion transport regulator 2
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
GPC3 glypican 3
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LCN2 lipocalin 2
LITAF lipopolysaccharide-induced TNF factor
LRRC16A leucine rich repeat containing 16A
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MREG melanoregulin
MSLN mesothelin
MSMB microseminoprotein, beta-
MTUS1 microtubule associated tumor suppressor 1
MUC16 mucin 16, cell surface associated
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID1 nidogen 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ORM1 orosomucoid 1
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PXDN peroxidasin
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
TACSTD2 tumor-associated calcium signal transducer 2
THAP11 THAP domain containing 11
TMC5 transmembrane channel-like 5
VWA5A von Willebrand factor A domain containing 5A
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
CCL2 chemokine (C-C motif) ligand 2
CHIC2 cysteine-rich hydrophobic domain 2
DBT dihydrolipoamide branched chain transacylase E2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR3 early growth response 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ESR1 estrogen receptor 1
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
GSE1 Gse1 coiled-coil protein
HIST1H2BG histone cluster 1, H2bg
HK1 hexokinase 1
HMGB2 high mobility group box 2
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IL13RA2 interleukin 13 receptor, alpha 2
MAP2K3 mitogen-activated protein kinase kinase 3
MT1G metallothionein 1G
ODC1 ornithine decarboxylase 1
PDLIM1 PDZ and LIM domain 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
RFC2 replication factor C (activator 1) 2, 40kDa
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
TFF3 trefoil factor 3 (intestinal)
TOP2A topoisomerase (DNA) II alpha 170kDa