BRD-A32595718_CVF-CSC-7 BRD-A32595718_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

237 genes differentially expressed following the BRD-A32595718_CVF-CSC-7 BRD-A32595718_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
AKR1C1 aldo-keto reductase family 1, member C1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLGN calmegin
CTGF connective tissue growth factor
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGFR epidermal growth factor receptor
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPAS1 endothelial PAS domain protein 1
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FNDC3B fibronectin type III domain containing 3B
FOXO4 forkhead box O4
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOLT1B golgi transport 1B
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-E major histocompatibility complex, class I, E
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IL1A interleukin 1, alpha
IL6 interleukin 6
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KRT14 keratin 14, type I
KYNU kynureninase
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MIR22HG MIR22 host gene
MSLN mesothelin
MSMO1 methylsterol monooxygenase 1
MXI1 MAX interactor 1, dimerization protein
MZB1 marginal zone B and B1 cell-specific protein
NAMPT nicotinamide phosphoribosyltransferase
NCF2 neutrophil cytosolic factor 2
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
NMRK1 nicotinamide riboside kinase 1
NNMT nicotinamide N-methyltransferase
NPC1 Niemann-Pick disease, type C1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUCB2 nucleobindin 2
OFD1 oral-facial-digital syndrome 1
OPTN optineurin
OSER1 oxidative stress responsive serine-rich 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PI3 peptidase inhibitor 3, skin-derived
PLEKHA5 pleckstrin homology domain containing, family A member 5
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
PTX3 pentraxin 3, long
RAB9A RAB9A, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RIOK3 RIO kinase 3
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEC24A SEC24 family member A
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERINC3 serine incorporator 3
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQSTM1 sequestosome 1
SRGN serglycin
SSR4 signal sequence receptor, delta
TFE3 transcription factor binding to IGHM enhancer 3
TMEM41B transmembrane protein 41B
TNIP1 TNFAIP3 interacting protein 1
TRIM29 tripartite motif containing 29
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK4 adenylate kinase 4
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
C20ORF27 chromosome 20 open reading frame 27
C7 complement component 7
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CD320 CD320 molecule
CDC25A cell division cycle 25A
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EPN2 epsin 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
FUS FUS RNA binding protein
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPNMB glycoprotein (transmembrane) nmb
GSTM3 glutathione S-transferase mu 3 (brain)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ICMT isoprenylcysteine carboxyl methyltransferase
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPH non-SMC condensin I complex, subunit H
NREP neuronal regeneration related protein
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAD54B RAD54 homolog B (S. cerevisiae)
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC4 structural maintenance of chromosomes 4
SRM spermidine synthase
SRSF1 serine/arginine-rich splicing factor 1
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFDP1 transcription factor Dp-1
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
ZWINT ZW10 interacting kinetochore protein