BRD-A28422330_4-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-A28422330_4-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANO1 anoctamin 1, calcium activated chloride channel
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
CARS cysteinyl-tRNA synthetase
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ENO2 enolase 2 (gamma, neuronal)
FAM129A family with sequence similarity 129, member A
FLG filaggrin
G0S2 G0/G1 switch 2
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
LIF leukemia inhibitory factor
LMO4 LIM domain only 4
MAGEA6 melanoma antigen family A6
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHYH phytanoyl-CoA 2-hydroxylase
PPARD peroxisome proliferator-activated receptor delta
PSAT1 phosphoserine aminotransferase 1
RAB25 RAB25, member RAS oncogene family
S100A14 S100 calcium binding protein A14
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ANPEP alanyl (membrane) aminopeptidase
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BAX BCL2-associated X protein
CD320 CD320 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COCH cochlin
COL4A1 collagen, type IV, alpha 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCN decorin
FGFR3 fibroblast growth factor receptor 3
FNBP1 formin binding protein 1
GOLGA8H golgin A8 family, member H
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IL27RA interleukin 27 receptor, alpha
LPAR6 lysophosphatidic acid receptor 6
METTL7A methyltransferase like 7A
NID1 nidogen 1
OLFM1 olfactomedin 1
PBX3 pre-B-cell leukemia homeobox 3
PVALB parvalbumin
RELN reelin
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRGN serglycin
STOM stomatin
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TXNIP thioredoxin interacting protein
XIST X inactive specific transcript (non-protein coding)
ZIC1 Zic family member 1