BRD-A26032986_CGS 9343B_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-A26032986_CGS 9343B_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAT1 adenosine deaminase, tRNA-specific 1
ADIRF adipogenesis regulatory factor
ARL4C ADP-ribosylation factor-like 4C
BCL7B B-cell CLL/lymphoma 7B
BLNK B-cell linker
BMP4 bone morphogenetic protein 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CES2 carboxylesterase 2
CFD complement factor D (adipsin)
CLDN3 claudin 3
COL15A1 collagen, type XV, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CST6 cystatin E/M
CTSH cathepsin H
DEFA5 defensin, alpha 5, Paneth cell-specific
DES desmin
DKK3 dickkopf WNT signaling pathway inhibitor 3
EMX2 empty spiracles homeobox 2
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
F13A1 coagulation factor XIII, A1 polypeptide
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
FKBP4 FK506 binding protein 4, 59kDa
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
H2AFY H2A histone family, member Y
HES1 hes family bHLH transcription factor 1
HK2 hexokinase 2
HOMER3 homer scaffolding protein 3
HPCAL1 hippocalcin-like 1
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
IPO13 importin 13
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
LDB3 LIM domain binding 3
LPAR6 lysophosphatidic acid receptor 6
LSR lipolysis stimulated lipoprotein receptor
LYZ lysozyme
MAN1C1 mannosidase, alpha, class 1C, member 1
MANSC1 MANSC domain containing 1
MAP7 microtubule-associated protein 7
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MDK midkine (neurite growth-promoting factor 2)
MEF2C myocyte enhancer factor 2C
MMP2 matrix metallopeptidase 2
MSLN mesothelin
MSMB microseminoprotein, beta-
NCAPD2 non-SMC condensin I complex, subunit D2
NCF2 neutrophil cytosolic factor 2
NELL2 NEL-like 2 (chicken)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NRN1 neuritin 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLVAP plasmalemma vesicle associated protein
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRSS8 protease, serine, 8
PRUNE2 prune homolog 2 (Drosophila)
PSD3 pleckstrin and Sec7 domain containing 3
PSPH phosphoserine phosphatase
PTPRO protein tyrosine phosphatase, receptor type, O
RAB25 RAB25, member RAS oncogene family
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RPL37A ribosomal protein L37a
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC1 syndecan 1
SHB Src homology 2 domain containing adaptor protein B
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPINK4 serine peptidase inhibitor, Kazal type 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
VCAN versican
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
WFDC1 WAP four-disulfide core domain 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF750 zinc finger protein 750

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ALCAM activated leukocyte cell adhesion molecule
ALDOA aldolase A, fructose-bisphosphate
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CD59 CD59 molecule, complement regulatory protein
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHL1 cell adhesion molecule L1-like
CSNK1G3 casein kinase 1, gamma 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DICER1 dicer 1, ribonuclease type III
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
ENO1 enolase 1, (alpha)
FNDC3B fibronectin type III domain containing 3B
GLIPR1 GLI pathogenesis-related 1
HK1 hexokinase 1
LAMP5 lysosomal-associated membrane protein family, member 5
LPL lipoprotein lipase
LTBP3 latent transforming growth factor beta binding protein 3
LYPLA1 lysophospholipase I
MATN2 matrilin 2
MBNL2 muscleblind-like splicing regulator 2
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MEF2A myocyte enhancer factor 2A
MPZL1 myelin protein zero-like 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKTR natural killer cell triggering receptor
NPR3 natriuretic peptide receptor 3
NR1D2 nuclear receptor subfamily 1, group D, member 2
OAT ornithine aminotransferase
OXTR oxytocin receptor
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM5 PDZ and LIM domain 5
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PITRM1 pitrilysin metallopeptidase 1
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RBM5 RNA binding motif protein 5
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REEP5 receptor accessory protein 5
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RUFY3 RUN and FYVE domain containing 3
SF3B1 splicing factor 3b, subunit 1, 155kDa
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TES testin LIM domain protein
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNPO1 transportin 1
TOP2B topoisomerase (DNA) II beta 180kDa
TRAK2 trafficking protein, kinesin binding 2
TSPAN3 tetraspanin 3
TUSC3 tumor suppressor candidate 3
TXNDC9 thioredoxin domain containing 9