BRD-A25004090_erastin_A375_24.0_h_4.8_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-A25004090_erastin_A375_24.0_h_4.8_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOB aldolase B, fructose-bisphosphate
ANK2 ankyrin 2, neuronal
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRABP2 cellular retinoic acid binding protein 2
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EPRS glutamyl-prolyl-tRNA synthetase
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IARS isoleucyl-tRNA synthetase
INHBE inhibin, beta E
JCHAIN joining chain of multimeric IgA and IgM
MARS methionyl-tRNA synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NARS asparaginyl-tRNA synthetase
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
PYCR1 pyrroline-5-carboxylate reductase 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSL24D1 ribosomal L24 domain containing 1
SARS seryl-tRNA synthetase
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A6 solute carrier family 16, member 6
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANOS1 anosmin 1
BAD BCL2-associated agonist of cell death
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
DHCR24 24-dehydrocholesterol reductase
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FSCN1 fascin actin-bundling protein 1
GAS2L1 growth arrest-specific 2 like 1
KIF20A kinesin family member 20A
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MMP9 matrix metallopeptidase 9
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PRKCA protein kinase C, alpha
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TIMP3 TIMP metallopeptidase inhibitor 3