BRD-A24429032_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-A24429032_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADAM10 ADAM metallopeptidase domain 10
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
BLVRB biliverdin reductase B
CBX1 chromobox homolog 1
CCR7 chemokine (C-C motif) receptor 7
CES1 carboxylesterase 1
CLU clusterin
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
FOLR1 folate receptor 1 (adult)
GCLM glutamate-cysteine ligase, modifier subunit
GREM1 gremlin 1, DAN family BMP antagonist
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
LOX lysyl oxidase
MMP10 matrix metallopeptidase 10
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
NLRP2 NLR family, pyrin domain containing 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NTS neurotensin
PIR pirin (iron-binding nuclear protein)
RND3 Rho family GTPase 3
SCGB1D2 secretoglobin, family 1D, member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD1 SMAD family member 1
SNX11 sorting nexin 11
SQSTM1 sequestosome 1
SRGN serglycin
TDO2 tryptophan 2,3-dioxygenase
TNC tenascin C
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
CAPN2 calpain 2, (m/II) large subunit
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CLCA1 chloride channel accessory 1
CXCL12 chemokine (C-X-C motif) ligand 12
DLD dihydrolipoamide dehydrogenase
FHL1 four and a half LIM domains 1
GRB14 growth factor receptor-bound protein 14
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
NKG7 natural killer cell granule protein 7
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLP1 proteolipid protein 1
PSD3 pleckstrin and Sec7 domain containing 3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
S100A10 S100 calcium binding protein A10
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPINK4 serine peptidase inhibitor, Kazal type 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
VCAN versican