BRD-A24396574_celastrol_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-A24396574_celastrol_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
CD247 CD247 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD8A CD8a molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CTH cystathionine gamma-lyase
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EDN1 endothelin 1
EGR1 early growth response 1
EGR3 early growth response 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FNBP1L formin binding protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FYB FYN binding protein
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
ITK IL2-inducible T-cell kinase
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
LEF1 lymphoid enhancer-binding factor 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
PDGFA platelet-derived growth factor alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRF1 perforin 1 (pore forming protein)
PRRC2C proline-rich coiled-coil 2C
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAD23B RAD23 homolog B (S. cerevisiae)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RND1 Rho family GTPase 1
RND3 Rho family GTPase 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPP1 secreted phosphoprotein 1
TBC1D31 TBC1 domain family, member 31
TBX3 T-box 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TES testin LIM domain protein
TESC tescalcin
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRAF5 TNF receptor-associated factor 5
TRBC1 T cell receptor beta constant 1
VEGFA vascular endothelial growth factor A
WBP5 WW domain binding protein 5
WEE1 WEE1 G2 checkpoint kinase
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF281 zinc finger protein 281

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
ALCAM activated leukocyte cell adhesion molecule
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA3 annexin A3
ARMCX2 armadillo repeat containing, X-linked 2
C3 complement component 3
CA2 carbonic anhydrase II
CAPG capping protein (actin filament), gelsolin-like
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHRDL1 chordin-like 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN8 claudin 8
CPA3 carboxypeptidase A3 (mast cell)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSS cathepsin S
CX3CL1 chemokine (C-X3-C motif) ligand 1
CYBA cytochrome b-245, alpha polypeptide
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
EREG epiregulin
FST follistatin
GJA1 gap junction protein, alpha 1, 43kDa
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
HLA-B major histocompatibility complex, class I, B
KCTD14 potassium channel tetramerization domain containing 14
KRT23 keratin 23, type I
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTF lactotransferrin
MYOF myoferlin
PCNA proliferating cell nuclear antigen
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PTPRK protein tyrosine phosphatase, receptor type, K
PUF60 poly-U binding splicing factor 60KDa
RAB11FIP1 RAB11 family interacting protein 1 (class I)
S100A6 S100 calcium binding protein A6
S100A7 S100 calcium binding protein A7
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SEPHS1 selenophosphate synthetase 1
SLPI secretory leukocyte peptidase inhibitor
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
TACSTD2 tumor-associated calcium signal transducer 2
TF transferrin
TNIP1 TNFAIP3 interacting protein 1
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TUBB6 tubulin, beta 6 class V
YME1L1 YME1-like 1 ATPase