BRD-A24396574_celastrol_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-A24396574_celastrol_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BEX1 brain expressed, X-linked 1
C14ORF132 chromosome 14 open reading frame 132
CADM1 cell adhesion molecule 1
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPT1A carnitine palmitoyltransferase 1A (liver)
CTSA cathepsin A
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R2 cytochrome b5 reductase 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DSP desmoplakin
DUSP5 dual specificity phosphatase 5
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPCAM epithelial cell adhesion molecule
FAM46A family with sequence similarity 46, member A
FOSL1 FOS-like antigen 1
G6PD glucose-6-phosphate dehydrogenase
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GPNMB glycoprotein (transmembrane) nmb
HMOX1 heme oxygenase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
KRT18 keratin 18, type I
LAMP3 lysosomal-associated membrane protein 3
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NQO1 NAD(P)H dehydrogenase, quinone 1
PLA2G16 phospholipase A2, group XVI
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
S100A12 S100 calcium binding protein A12
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TPBG trophoblast glycoprotein

decreased expression

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
C7 complement component 7
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CDC42 cell division cycle 42
CDC5L cell division cycle 5-like
CDK1 cyclin-dependent kinase 1
CFH complement factor H
COL3A1 collagen, type III, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CXCL10 chemokine (C-X-C motif) ligand 10
CYTL1 cytokine-like 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
GATA2 GATA binding protein 2
GBP1 guanylate binding protein 1, interferon-inducible
GOLT1B golgi transport 1B
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HLA-DRA major histocompatibility complex, class II, DR alpha
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
KIAA1033 KIAA1033
LOXL1 lysyl oxidase-like 1
LRRC17 leucine rich repeat containing 17
MED21 mediator complex subunit 21
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDLIM3 PDZ and LIM domain 3
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TAGLN transgelin
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase