BRD-A24396574_celastrol_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

200 genes differentially expressed following the BRD-A24396574_celastrol_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA2 acetyl-CoA acyltransferase 2
ACKR3 atypical chemokine receptor 3
ACSS3 acyl-CoA synthetase short-chain family member 3
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARG1 arginase 1
ASPN asporin
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C5AR1 complement component 5a receptor 1
CCL20 chemokine (C-C motif) ligand 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL15A1 collagen, type XV, alpha 1
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
ECHDC2 enoyl CoA hydratase domain containing 2
EGR1 early growth response 1
EGR3 early growth response 3
ELANE elastase, neutrophil expressed
F13A1 coagulation factor XIII, A1 polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FILIP1L filamin A interacting protein 1-like
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GAB2 GRB2-associated binding protein 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GOLT1B golgi transport 1B
GPNMB glycoprotein (transmembrane) nmb
GPRASP1 G protein-coupled receptor associated sorting protein 1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IFRD2 interferon-related developmental regulator 2
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
LDLR low density lipoprotein receptor
LIN7A lin-7 homolog A (C. elegans)
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2 microtubule-associated protein 2
MIR22HG MIR22 host gene
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OASL 2'-5'-oligoadenylate synthetase-like
PEG3 paternally expressed 3
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RANBP9 RAN binding protein 9
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RORA RAR-related orphan receptor A
S100P S100 calcium binding protein P
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC35G2 solute carrier family 35, member G2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
STXBP6 syntaxin binding protein 6 (amisyn)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TPBG trophoblast glycoprotein
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TYROBP TYRO protein tyrosine kinase binding protein
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAM10 ADAM metallopeptidase domain 10
ADGRG6 adhesion G protein-coupled receptor G6
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATMIN ATM interactor
ATP10D ATPase, class V, type 10D
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BICC1 BicC family RNA binding protein 1
BIRC5 baculoviral IAP repeat containing 5
BTN3A2 butyrophilin, subfamily 3, member A2
C2CD2 C2 calcium-dependent domain containing 2
CDC25B cell division cycle 25B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK19 cyclin-dependent kinase 19
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
COG4 component of oligomeric golgi complex 4
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAPK1 death-associated protein kinase 1
DHCR24 24-dehydrocholesterol reductase
ERBB2 erb-b2 receptor tyrosine kinase 2
ERMP1 endoplasmic reticulum metallopeptidase 1
FGFR2 fibroblast growth factor receptor 2
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GSTP1 glutathione S-transferase pi 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JCHAIN joining chain of multimeric IgA and IgM
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LY6E lymphocyte antigen 6 complex, locus E
LY75 lymphocyte antigen 75
MALL mal, T-cell differentiation protein-like
MBNL2 muscleblind-like splicing regulator 2
MLEC malectin
MMP7 matrix metallopeptidase 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEK2 NIMA-related kinase 2
NNMT nicotinamide N-methyltransferase
NOTCH2 notch 2
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OPN3 opsin 3
P3H2 prolyl 3-hydroxylase 2
PGAM1 phosphoglycerate mutase 1 (brain)
PHKB phosphorylase kinase, beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKCZ protein kinase C, zeta
PUF60 poly-U binding splicing factor 60KDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPN1 ribophorin I
RRP1B ribosomal RNA processing 1B
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBL1X transducin (beta)-like 1X-linked
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TGM2 transglutaminase 2
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
WFS1 Wolfram syndrome 1 (wolframin)
ZNF185 zinc finger protein 185 (LIM domain)