BRD-A19500257_geldanamycin_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-A19500257_geldanamycin_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
AKAP9 A kinase (PRKA) anchor protein 9
BAG3 BCL2-associated athanogene 3
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CTBS chitobiase, di-N-acetyl-
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FABP7 fatty acid binding protein 7, brain
FBXO11 F-box protein 11
FOSL2 FOS-like antigen 2
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOLGB1 golgin B1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
ITM2C integral membrane protein 2C
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KIAA1033 KIAA1033
LYN LYN proto-oncogene, Src family tyrosine kinase
MANF mesencephalic astrocyte-derived neurotrophic factor
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MBNL2 muscleblind-like splicing regulator 2
MGAM maltase-glucoamylase
MSLN mesothelin
MT1X metallothionein 1X
MUT methylmalonyl CoA mutase
NDRG1 N-myc downstream regulated 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NPR3 natriuretic peptide receptor 3
PCGF2 polycomb group ring finger 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RHOBTB3 Rho-related BTB domain containing 3
RNF13 ring finger protein 13
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERP1 stress-associated endoplasmic reticulum protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPAG16 sperm associated antigen 16
STXBP2 syntaxin binding protein 2
SUCO SUN domain containing ossification factor
SYNM synemin, intermediate filament protein
SYT1 synaptotagmin I
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFA transforming growth factor, alpha
TM9SF3 transmembrane 9 superfamily member 3
TMED9 transmembrane emp24 protein transport domain containing 9
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AREG amphiregulin
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
BMP2 bone morphogenetic protein 2
BTBD3 BTB (POZ) domain containing 3
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CCL19 chemokine (C-C motif) ligand 19
CCND1 cyclin D1
CD200 CD200 molecule
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLU clusterin
COMP cartilage oligomeric matrix protein
CXADR coxsackie virus and adenovirus receptor
CXCL11 chemokine (C-X-C motif) ligand 11
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCT dopachrome tautomerase
EGR3 early growth response 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAS Fas cell surface death receptor
FGFR2 fibroblast growth factor receptor 2
GAL galanin/GMAP prepropeptide
GRB14 growth factor receptor-bound protein 14
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KRT17 keratin 17, type I
LTF lactotransferrin
METTL7A methyltransferase like 7A
MMP9 matrix metallopeptidase 9
MPZL2 myelin protein zero-like 2
MSH6 mutS homolog 6
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
OXA1L oxidase (cytochrome c) assembly 1-like
PLK1 polo-like kinase 1
PLP1 proteolipid protein 1
PRKCD protein kinase C, delta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RELN reelin
RGS4 regulator of G-protein signaling 4
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAMHD1 SAM domain and HD domain 1
SCGB2A2 secretoglobin, family 2A, member 2
SLPI secretory leukocyte peptidase inhibitor
SPP1 secreted phosphoprotein 1
SSBP1 single-stranded DNA binding protein 1, mitochondrial
TFPI2 tissue factor pathway inhibitor 2
TOX3 TOX high mobility group box family member 3
TTC39A tetratricopeptide repeat domain 39A
VCAM1 vascular cell adhesion molecule 1
XIST X inactive specific transcript (non-protein coding)
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZEB2 zinc finger E-box binding homeobox 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF43 zinc finger protein 43