BRD-A19500257_geldanamycin_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

367 genes differentially expressed following the BRD-A19500257_geldanamycin_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACP1 acid phosphatase 1, soluble
ACSL3 acyl-CoA synthetase long-chain family member 3
ADI1 acireductone dioxygenase 1
ADM adrenomedullin
AFF1 AF4/FMR2 family, member 1
AKAP9 A kinase (PRKA) anchor protein 9
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX1 armadillo repeat containing, X-linked 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBX bobby sox homolog (Drosophila)
BCAM basal cell adhesion molecule (Lutheran blood group)
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPIFA1 BPI fold containing family A, member 1
BRD8 bromodomain containing 8
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CAB39 calcium binding protein 39
CALCOCO1 calcium binding and coiled-coil domain 1
CALU calumenin
CCDC28A coiled-coil domain containing 28A
CCNG1 cyclin G1
CCNG2 cyclin G2
CD163 CD163 molecule
CD24 CD24 molecule
CD46 CD46 molecule, complement regulatory protein
CD59 CD59 molecule, complement regulatory protein
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK19 cyclin-dependent kinase 19
CES1 carboxylesterase 1
COBL cordon-bleu WH2 repeat protein
COL4A5 collagen, type IV, alpha 5
CREB3L2 cAMP responsive element binding protein 3-like 2
CRYZ crystallin, zeta (quinone reductase)
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAZAP2 DAZ associated protein 2
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DIAPH2 diaphanous-related formin 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EFCAB14 EF-hand calcium binding domain 14
EGF epidermal growth factor
EGFL6 EGF-like-domain, multiple 6
EIF4B eukaryotic translation initiation factor 4B
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
EXOSC4 exosome component 4
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FBN2 fibrillin 2
FOXJ3 forkhead box J3
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA2 GATA binding protein 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GOLGB1 golgin B1
GPC4 glypican 4
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
H3F3B H3 histone, family 3B (H3.3B)
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSBP1 heat shock factor binding protein 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
INSIG2 insulin induced gene 2
INSR insulin receptor
IRS2 insulin receptor substrate 2
JUP junction plakoglobin
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLHDC10 kelch domain containing 10
KLHL24 kelch-like family member 24
LDHB lactate dehydrogenase B
LETMD1 LETM1 domain containing 1
LITAF lipopolysaccharide-induced TNF factor
LOC100272216 uncharacterized LOC100272216
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MAOA monoamine oxidase A
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MID1 midline 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOAP1 modulator of apoptosis 1
MOB1A MOB kinase activator 1A
MXI1 MAX interactor 1, dimerization protein
MYLIP myosin regulatory light chain interacting protein
NAV2 neuron navigator 2
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEU1 sialidase 1 (lysosomal sialidase)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NOTCH2NL notch 2 N-terminal like
NPTX2 neuronal pentraxin II
NUCB2 nucleobindin 2
OBSL1 obscurin-like 1
OGDHL oxoglutarate dehydrogenase-like
OSBPL9 oxysterol binding protein-like 9
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PFKM phosphofructokinase, muscle
PFN2 profilin 2
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNRC1 proline-rich nuclear receptor coactivator 1
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
PRSS8 protease, serine, 8
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QPRT quinolinate phosphoribosyltransferase
RAB17 RAB17, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM47 RNA binding motif protein 47
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL31 ribosomal protein L31
RPS27L ribosomal protein S27-like
S100A4 S100 calcium binding protein A4
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SECISBP2L SECIS binding protein 2-like
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERINC1 serine incorporator 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SFRP1 secreted frizzled-related protein 1
SOCS2 suppressor of cytokine signaling 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STC1 stanniocalcin 1
STOM stomatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THSD7A thrombospondin, type I, domain containing 7A
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
UBXN7 UBX domain protein 7
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB38 zinc finger and BTB domain containing 38
ZMAT3 zinc finger, matrin-type 3
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ABLIM1 actin binding LIM protein 1
ACTN1 actinin, alpha 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK4 adenylate kinase 4
ALOX5 arachidonate 5-lipoxygenase
ANXA5 annexin A5
APOC1 apolipoprotein C-I
AREG amphiregulin
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BHLHE41 basic helix-loop-helix family, member e41
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
BYSL bystin-like
C14ORF169 chromosome 14 open reading frame 169
C1ORF116 chromosome 1 open reading frame 116
C20ORF27 chromosome 20 open reading frame 27
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CCNE2 cyclin E2
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK4 cyclin-dependent kinase 4
CECR5 cat eye syndrome chromosome region, candidate 5
CENPU centromere protein U
CHEK1 checkpoint kinase 1
CKLF chemokine-like factor
CLTB clathrin, light chain B
COTL1 coactosin-like F-actin binding protein 1
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
DCTPP1 dCTP pyrophosphatase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DESI1 desumoylating isopeptidase 1
DHFR dihydrofolate reductase
DLC1 DLC1 Rho GTPase activating protein
DNM1L dynamin 1-like
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DONSON downstream neighbor of SON
DPH2 DPH2 homolog (S. cerevisiae)
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EGR3 early growth response 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EREG epiregulin
ETV1 ets variant 1
EXOSC2 exosome component 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FANCG Fanconi anemia, complementation group G
FEN1 flap structure-specific endonuclease 1
G0S2 G0/G1 switch 2
GALE UDP-galactose-4-epimerase
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX2 glutaredoxin 2
GPM6A glycoprotein M6A
H2AFX H2A histone family, member X
HBEGF heparin-binding EGF-like growth factor
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOMER2 homer scaffolding protein 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGKC immunoglobulin kappa constant
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO4 importin 4
IRF8 interferon regulatory factor 8
ITM2A integral membrane protein 2A
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT16 keratin 16, type I
LAGE3 L antigen family, member 3
LHFP lipoma HMGIC fusion partner
LOXL1 lysyl oxidase-like 1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYZ lysozyme
MALL mal, T-cell differentiation protein-like
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MREG melanoregulin
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
NRIP1 nuclear receptor interacting protein 1
NXT1 nuclear transport factor 2-like export factor 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEA15 phosphoprotein enriched in astrocytes 15
PFAS phosphoribosylformylglycinamidine synthase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPA1 pyrophosphatase (inorganic) 1
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCI protein kinase C, iota
PRPF19 pre-mRNA processing factor 19
PSIP1 PC4 and SFRS1 interacting protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRE protein tyrosine phosphatase, receptor type, E
PUS1 pseudouridylate synthase 1
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCR1 pyrroline-5-carboxylate reductase 1
RANBP1 RAN binding protein 1
RBBP8 retinoblastoma binding protein 8
RFC3 replication factor C (activator 1) 3, 38kDa
RFTN1 raftlin, lipid raft linker 1
RMI1 RecQ mediated genome instability 1
RNASEH2A ribonuclease H2, subunit A
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
S100A7 S100 calcium binding protein A7
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SRM spermidine synthase
TAGLN transgelin
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TEAD4 TEA domain family member 4
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
ZWINT ZW10 interacting kinetochore protein