BRD-A19500257_geldanamycin_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-A19500257_geldanamycin_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
AKR1C1 aldo-keto reductase family 1, member C1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BPIFA1 BPI fold containing family A, member 1
C3 complement component 3
C4BPA complement component 4 binding protein, alpha
CAPN6 calpain 6
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHPT1 choline phosphotransferase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COL2A1 collagen, type II, alpha 1
CRELD2 cysteine-rich with EGF-like domains 2
CRTC3 CREB regulated transcription coactivator 3
CTSH cathepsin H
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPAS1 endothelial PAS domain protein 1
FCMR Fc fragment of IgM receptor
GDF15 growth differentiation factor 15
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPER1 G protein-coupled estrogen receptor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
INHBE inhibin, beta E
IRS2 insulin receptor substrate 2
KAT6B K(lysine) acetyltransferase 6B
KRT7 keratin 7, type II
LYN LYN proto-oncogene, Src family tyrosine kinase
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MSLN mesothelin
MSMB microseminoprotein, beta-
NFIL3 nuclear factor, interleukin 3 regulated
NGRN neugrin, neurite outgrowth associated
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OSER1 oxidative stress responsive serine-rich 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2AF1 POU class 2 associating factor 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RAD9A RAD9 homolog A (S. pombe)
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPS11 ribosomal protein S11
RSL1D1 ribosomal L1 domain containing 1
S100P S100 calcium binding protein P
SDF2L1 stromal cell-derived factor 2-like 1
SERP1 stress-associated endoplasmic reticulum protein 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SGK1 serum/glucocorticoid regulated kinase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC35B1 solute carrier family 35, member B1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC43A3 solute carrier family 43, member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPATS2L spermatogenesis associated, serine-rich 2-like
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
THBS1 thrombospondin 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TRA2A transformer 2 alpha homolog (Drosophila)
TRBC1 T cell receptor beta constant 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPYL5 TSPY-like 5
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADGRL2 adhesion G protein-coupled receptor L2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AREG amphiregulin
ASPH aspartate beta-hydroxylase
BEX1 brain expressed, X-linked 1
BMP2 bone morphogenetic protein 2
BST2 bone marrow stromal cell antigen 2
C3ORF14 chromosome 3 open reading frame 14
CCNF cyclin F
CD200 CD200 molecule
CKB creatine kinase, brain
CLIC3 chloride intracellular channel 3
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DUSP22 dual specificity phosphatase 22
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ELANE elastase, neutrophil expressed
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERLIN2 ER lipid raft associated 2
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GAL galanin/GMAP prepropeptide
GAS1 growth arrest-specific 1
GRB14 growth factor receptor-bound protein 14
GSTM3 glutathione S-transferase mu 3 (brain)
HES1 hes family bHLH transcription factor 1
HOXA5 homeobox A5
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
KAZN kazrin, periplakin interacting protein
KLK6 kallikrein-related peptidase 6
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
MMP9 matrix metallopeptidase 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NID2 nidogen 2 (osteonidogen)
NOTCH2 notch 2
NPTX2 neuronal pentraxin II
NRN1 neuritin 1
OLFM4 olfactomedin 4
ORC1 origin recognition complex, subunit 1
PDGFD platelet derived growth factor D
PI3 peptidase inhibitor 3, skin-derived
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PRAME preferentially expressed antigen in melanoma
PRTN3 proteinase 3
QPCT glutaminyl-peptide cyclotransferase
RNH1 ribonuclease/angiogenin inhibitor 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SKAP2 src kinase associated phosphoprotein 2
STAR steroidogenic acute regulatory protein
STC1 stanniocalcin 1
STON1 stonin 1
TALDO1 transaldolase 1
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TYRP1 tyrosinase-related protein 1
VCAN versican
VGLL4 vestigial-like family member 4
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36L2 ZFP36 ring finger protein-like 2