BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-A18725729_2-[(chloroacetyl)(4-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAG3 BCL2-associated athanogene 3
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
FGFR2 fibroblast growth factor receptor 2
GCLM glutamate-cysteine ligase, modifier subunit
GPM6B glycoprotein M6B
GPR137B G protein-coupled receptor 137B
HEPH hephaestin
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLK10 kallikrein-related peptidase 10
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MME membrane metallo-endopeptidase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
PELI1 pellino E3 ubiquitin protein ligase 1
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRR15L proline rich 15-like
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAD Ras-related associated with diabetes
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
TUBB2A tubulin, beta 2A class IIa
UFD1L ubiquitin fusion degradation 1 like (yeast)

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AURKA aurora kinase A
B3GNT1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND2 cyclin D2
CCNF cyclin F
CENPA centromere protein A
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GNAS GNAS complex locus
HMMR hyaluronan-mediated motility receptor (RHAMM)
IL1B interleukin 1, beta
ISOC1 isochorismatase domain containing 1
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGED1 melanoma antigen family D1
MFAP4 microfibrillar-associated protein 4
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
OXTR oxytocin receptor
PEG3 paternally expressed 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSRC1 proline/serine-rich coiled-coil 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDL1 spindle apparatus coiled-coil protein 1
SPTBN1 spectrin, beta, non-erythrocytic 1
STMN1 stathmin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOP2A topoisomerase (DNA) II alpha 170kDa
TXNL4B thioredoxin-like 4B
TYRP1 tyrosinase-related protein 1
USP22 ubiquitin specific peptidase 22